Enhanced production of nitric oxide,reactive oxygen species,and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Enhanced production of nitric oxide,reactive oxygen species,and pro-inflammatory cytokines in very long chain saturated fatty acid-accumulated macrophages

Authors:	Naotake Yanagisawa Kazunori Shimada Tetsuro Miyazaki Atsumi Kume Yohei Kitamura Katsuhiko Sumiyoshi Takashi Kiyanagi Takafumi Iesaki Nao Inoue Hiroyuki Daida

Affiliation:	(1) Department of Cardiovascular Medicine, Juntendo University School of Medicine, Tokyo, Japan;(2) Nutritional Science Institute, Morinaga Milk Industry Co., Ltd, Kanagawa, Japan;(3) Department of Organ and Cell Physiology, Juntendo University School of Medicine, Tokyo, Japan

Abstract:	Background Deterioration of peroxisomal β-oxidation activity causes an accumulation of very long chain saturated fatty acids (VLCSFA) in various organs. We have recently reported that the levels of VLCSFA in the plasma and/or membranes of blood cells were significantly higher in patients with metabolic syndrome and in patients with coronary artery disease than the controls. The aim of the present study is to investigate the effect of VLCSFA accumulation on inflammatory and oxidative responses in VLCSFA-accumulated macrophages derived from X-linked adrenoleukodystrophy (X-ALD) protein (ALDP)-deficient mice.

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