| 丹参毛状根对麻醉大鼠心肌缺血再灌注损伤的保护作用 |
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| 引用本文： | 吕冬梅,王岚,梁日欣,袁媛,黄璐琦. 丹参毛状根对麻醉大鼠心肌缺血再灌注损伤的保护作用[J]. 中国实验方剂学杂志, 2009, 15(3): 27-28 |
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| 作者姓名： | 吕冬梅 王岚 梁日欣 袁媛 黄璐琦 |
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| 作者单位： | 中国中医科学院中药研究所,北京,100700 |
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| 基金项目： | 国家重点基础研究发展规划(973计划)，国家高技术研究发展计划(863计划) |
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| 摘 要： | 目的:研究丹参毛状根对麻醉大鼠心肌缺血再灌注损伤的保护作用。方法:采用大鼠冠脉结扎致心肌缺血模型。结果:丹参毛状根能显著降低缺血所致室速(VT),室颤(VF)的发生率,降低血浆乳酸脱氢酶(LDH)、丙二醛(MDA)增高程度,提高超氧化物歧化酶(SOD)活性,与丹参药材比较无显著性差异。结论:丹参毛状根具有和丹参相似的药理作用,为其进一步的研究与开发利用,提供了实验依据。
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| 关 键 词： | 丹参毛状根 大鼠 心肌缺血再灌注损伤 保护作用 |
| 收稿时间： | 2008-06-23 |
Protection on Myocardial Ischemia and Reperfusion Injury in Anesthetized Rat by Salvia miltiorrhiza Hairy Root |
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| LV Dong-mei,WANG Lan,LIANG Ri-xin,YUAN Yuan,HUANG Lu-qi. Protection on Myocardial Ischemia and Reperfusion Injury in Anesthetized Rat by Salvia miltiorrhiza Hairy Root[J]. China Journal of Experimental Traditional Medical Formulae, 2009, 15(3): 27-28 |
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| Authors: | LV Dong-mei WANG Lan LIANG Ri-xin YUAN Yuan HUANG Lu-qi |
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| Affiliation: | Institute of Chinese Materia Medica,China Academy of Chinese Medicinal Sciences,Beijing 100700,China |
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| Abstract: | The protection on myocardial ischemia and reperfusion injury in intact rats by Salvia miltiorrhiza hairy root was investigated.The result showed that the protection induced by Salvia miltiorrhiza hairy root reduced the incidence of ventricular tachycardia(VT) and ventricular fibrillation(VF) during the period of ischemia and reperfusion,the rise of plasma level of LDH,MDA decreased and the activity of SOD increased.However,there is no significant different between the hairy root and Salvia miltiorrhiza. |
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| Keywords: | Salvia miltiorrhiza hairy root rat myocardial ischemia and reperfusion injury protection |
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