| SO2吸入对小鼠骨髓细胞微核的诱发效应 |
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| 引用本文： | 孟紫强,阮爱东,张波,桑楠,张建彪.SO2吸入对小鼠骨髓细胞微核的诱发效应[J].环境与健康杂志,2002,19(4):298-299. |
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| 作者姓名： | 孟紫强 阮爱东 张波 桑楠 张建彪 |
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| 作者单位： | 山西大学环境医学与毒理学研究所,山西,太原,030006 |
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| 基金项目： | 国家自然科学基金资助项目（30070647） |
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| 摘 要： | 目的 探讨空气中SO2污染物遗传毒理效应。方法 采用SO2吸入染毒法，对SO2吸入诱发小鼠骨髓嗜多染红细胞（PCE）形成微核（MN）的效应进行研究。结果 （1）SO2吸入可引起小鼠骨髓PCE微核率和微核细胞率显著升高；（2）随着吸入的SO2浓度的增高，单微核细胞率、双微核细胞率均显著升高。结论 随SO2浓度增加，细胞遗传物质损伤加重，且有明确的剂量-效应关系，表明SO2空气污染物是染色体断裂剂和基因毒性因子。
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| 关 键 词： | 诱发效应 二氧化硫 微核 小鼠 骨髓细胞 遗传毒理 环境毒理学 |
| 文章编号： | 1001-5914(2002)04-0298-02 |
| 修稿时间： | 2001年11月9日 |
Micronuclei Induced by Sulfur Dioxide Inhalation in Bone Marrow Cells of Mice |
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| MENG Zi-qiang,RUAN Ai-dong,ZHANG Bo,et al..Micronuclei Induced by Sulfur Dioxide Inhalation in Bone Marrow Cells of Mice[J].Journal of Environment and Health,2002,19(4):298-299. |
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| Authors: | MENG Zi-qiang RUAN Ai-dong ZHANG Bo |
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| Institution: | MENG Zi-qiang,RUAN Ai-dong,ZHANG Bo,et al. Institute of Environmental Medicine and Toxicology,Department of Life Science,Shanxi University,Taiyuan 030006,China |
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| Abstract: | Objective To investigate the genetic toxicological effects of sulfur dioxide (SO2), a pollutant in air. Methods The inductive effects of SO2 inhalation on micronuclei formation in the polychromatophilic erythroblasts (PCE) of mouse bone marrow were studied. Results (1) SO2 inhalation caused a significant increase of both the frequency of micronuclei in PCE cells and the frequency of PCE cells with micronuclei; (2) In the PCE cells, both the frequency of cells with mono-micronuclei and the frequency of cells with bi-micronuclei were significantly increased as concentrations of SO2 increasing. Conclusion With the increase of concentrations of SO2, the damage of cytogenetic material became more serious and revealed a more clear dose-effect relationship. It suggested that SO2 was a clastogen and genotoxic agent. |
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| Keywords: | Sulfur dioxide Micronuclei Mouse bone marrow cells Genetic toxicity |
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