心理干预与复发性流产妊娠结局的研讨

目的 研究心理干预与复发性流产(recurrent spontaneous abortion,RSA)的关系。方法 选取2008年8月至2011年8月中山博爱医院妇产科收治的有复发性流产病史的先兆流产安胎患者200例,其中行心理干预100例为观察组,未行心理干预100例为对照组。用酶联免疫吸附法(enzyme linked immunosorbent assay,ELISA)及免疫放射法测定血清考的松(Cortisol)、血清孕酮(progesterone,P)、催乳素(prolactin,PRL)及人绒毛膜促性腺激素(human chorionic gonadotrophin,HCG)值,观察妊娠结局并对新生儿进行评估,分别进行新生儿行为神经测定(neonatal behavio-ral neurological assessment,NBNA)及神经元烯醇化酶(neuron specif-ic enolase,NSE)水平测定。结果 观察组患者血清中抗考的松含量、抑郁自评量表(self-rating depression scale,SDS)评分、汉密顿抑郁量表(Hamilton rating scale for depression,HAMD)评分明显高于C组(P<0.05),行心理干预后上述指标改善(P<0.05)。结论 心理干预对改善复发性流产患者妊娠结局及新生儿预后有较好的影响。

The relationship between psychological intervention and the outcomes of recurrent spontaneous abortion

Objective To analyze the relationship between psychological intervention and recurrent spontaneous abortion （RSA）. Methods From August 2008 to August 2011,200 women with RSA were hospitalized for anti -abortion in the Department of Obstetrics and Gynecology, Zhongshan Boai Hospital. They were classified into two groups, 100 cases with psychological intervention in observation group, others in control group. The values of cortisol,progesterone （P）,prolactin （PRL）,and human chorionie gonadotrophin （HCG） were tested by the method of enzyme linked immunosorbent assay （ELISA）, respectively. The pregnant outcomes and newborns were also assessed, including neonatal behavioral neurological assessment （NBNA） and neuron specific enolase （NSE） assessment. Results In observation group, cortisol contents, the scores of self - rating depression scale （SDS） and hamihon rating scale for depression （ HAMD ） were remarkably higher than control group （ P 〈 0. 05 ）. After psychological intervention, the above index have been improved （ P 〈 0.05 ）. Conclusion Psychological intervention is beneficial to the pregnant outcomes of RSA women, as well as newborns prognosis.