| 硝苯吡啶对吡喹酮在大鼠体内药代动力学影响 |
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| 引用本文： | 赵梁立 黄婉芸. 硝苯吡啶对吡喹酮在大鼠体内药代动力学影响[J]. 重庆医科大学学报, 1993, 18(4): 251-254 |
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| 作者姓名： | 赵梁立 黄婉芸 |
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| 作者单位： | 重庆医科大学药理学教研室(赵梁立，黄婉芸)，重庆医科大学药理学教研室(全钰珠) |
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| 摘 要： | ![]()
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| 关 键 词： | 吡喹酮 硝苯吡啶 药代动力学 |
EFFECT OF NIFEDIPINE ON PHARMACOKINETICS OF PRAZIQUANTEL IN RATS |
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| Zhao Liangli,et alDept of Pharmacology. EFFECT OF NIFEDIPINE ON PHARMACOKINETICS OF PRAZIQUANTEL IN RATS[J]. Journal of Chongqing Medical University, 1993, 18(4): 251-254 |
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| Authors: | Zhao Liangli et alDept of Pharmacology |
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| Abstract: | ![]()
A previous study in our laboratory had shown that n ifedipine(NF) as acalci-um antagonist, competitively inhibited the metabolism of praziquantel (PQT) enantiomers in human and rat liver microsomes in vitro. In this paper, we studied the effect of NF on the plasma concentration of PQT in rats. After Ig injections of PQT 100 mg/kg to male Wistar rats, the plasma levels of PQT were determined by reverse HPLC. The results shown by, (that)tho pharmacokinetic parameters (AUC, MRT, CL, Tmax and Cmax) of PQT in NF (a single ip injection of 40 mg/kg) -pretreated rats were not significantly differ3nt as compared with that of control rats. The data from our investigation demonstrated that NF had no effects on the pharmacokinetics of PQT in rats in vivo |
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| Keywords: | praziquantel nifsdipine pharmacokinetics drug interartions |
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