Hesperidin Suppresses Ovalbumin-Induced Airway Inflammation in a Mouse Allergic Asthma Model |
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Authors: | Dajun Wei Xinxin Ci Xiao Chu Miaomiao Wei Shucheng Hua Xuming Deng |
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Institution: | (1) The First Hospital of Jilin University, 71 Xinmin Road, Changchun, 130021, People’s Republic of China;(2) Key Laboratory of Zoonosis Research, Ministry of Education, Institute of Zoonosis, College of Animal Science and Veterinary Medicine, Jilin University, 5333 Xi’an Road, Changchun, 130062, People’s Republic of China;(3) Medical Department, Beihua University, 3999 Huashan Road, Jilin, 132013, People’s Republic of China; |
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Abstract: | Hesperidin, a flavanone glycoside comprised of the flavanone hesperetin and the disaccharide rutinose, is a plentiful and
inexpensive by-product of citrus cultivation. It has been reported to exert a wide range of pharmacological effects that include
antioxidant, anti-inflammatory, and anticarcinogenic properties. In this study, we attempt to determine whether hesperidin
inhibits inflammatory mediators in the mouse allergic asthma model. Mice were sensitized and challenged by ovalbumin (OVA)
to induce chronic airway inflammation and airway remodeling. The administration of hesperidin significantly decreased the
number of infiltrating inflammatory cells and Th2 cytokines in bronchoalveolar lavage (BAL) fluid compared with the OVA-induced
group of mice. In addition, hesperidin reduced OVA-specific IgE levels in serum. Hesperidin markedly alleviated the OVA-induced
airway hyperresponsiveness (AHR) to inhaled methacholine. Based on lung histopathological studies using hematoxylin and eosin
and alcian blue-periodic acid-Schiff staining, hesperidin inhibited inflammatory cell infiltration and mucus hypersecretion
compared with the OVA-induced group of mice. These findings provide new insight into the immunopharmacological role of hesperidin
in terms of its effects in a murine model of asthma. |
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