| 山柰苷的人肠内细菌生物转化研究 |
| |
| 引用本文： | 杨秀伟,张建业,徐嵬,李军,张蔚青. 山柰苷的人肠内细菌生物转化研究[J]. 药学学报, 2005, 40(8): 717-721 |
| |
| 作者姓名： | 杨秀伟 张建业 徐嵬 李军 张蔚青 |
| |
| 作者单位： | 北京大学,药学院,天然药物及仿生药物国家重点实验室,北京,100083 |
| |
| 基金项目： | 国家高技术研究发展计划(863计划)基金资助项目(2002AA2Z343C). |
| |
| 摘 要： | 目的探讨人肠内细菌对中药罗汉果中山柰苷的生物转化。方法采用人肠内细菌与山柰苷共温孵培养的方法，通过色谱技术分离、纯化转化产物，应用谱学技术确定转化产物的结构。结果人肠内细菌转化山柰苷产生山柰酚3-O-α-L-吡喃鼠李糖苷(阿福豆苷)、山柰酚7-O-α-L-吡喃鼠李糖苷、山柰酚和对-羟基苯甲酸。结论山柰苷可被人肠内细菌进行生物转化。
|
| 关 键 词： | 罗汉果 山柰苷 人肠内细菌 生物转化 |
| 文章编号： | 0513-4870（2005）08-0717-05 |
| 收稿时间： | 2004-11-11 |
| 修稿时间： | 2004-11-11 |
The biotransformation of kaempferitrin by human intestinal flora |
| |
| YANG Xiu-wei,ZHANG Jian-ye,XU Wei,LI Jun,ZHANG Wei-qing. The biotransformation of kaempferitrin by human intestinal flora[J]. Acta pharmaceutica Sinica, 2005, 40(8): 717-721 |
| |
| Authors: | YANG Xiu-wei ZHANG Jian-ye XU Wei LI Jun ZHANG Wei-qing |
| |
| Affiliation: | The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. xwyang@bjmu.edu.cn |
| |
| Abstract: | AIM: To study the biotransformation of kaempferitrin, a major chemical principle of the fruits of Siraitia grosvenori (Swingle) C. Jeffery, with human intestinal flora. METHODS: The kaempferitrin was incubated with human intestinal flora. The biotransformation products were isolated and purified by chromatographic methods and the structures were determined by spectroscopic techniques. RESULTS: Kaempferitrin was converted into kaempferol 3-O-alpha-L-rhamnoside (afzelin, I) , kaempferol 7-O-alpha-L-rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora. rhamnoside (II), kaempferol (III) and p-hydroxybenzoic acid (IV) by human intestinal flora. CONCLUSION: The structure of kaempferitrin can be biotransformatedly converted by human intestinal flora. |
| |
| Keywords: | Siraitia grosvenori kaempferitrin human intestinal flora biotransformation |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
| 点击此处可从《药学学报》浏览原始摘要信息 |
|
点击此处可从《药学学报》下载全文 |
|
