76例胃大部切除术后残胃癌临床分析

目的观察胃大部切除术后残胃癌的治疗及预后,分析其发生的可能相关因素。方法回顾693例接受胃大部切除术患者的临床资料。观察残胃癌的发生、治疗及其预后;同时就与残胃癌发生的可能相关因素进行统计学分析。结果693例胃大部切除术中,发生残胃癌76例。51例行手术治疗,其中36例行根治手术,15例行姑息性切除,围手术期无死亡病例,两种术式的中位生存期分别为32.7月和14.2月。未行手术切除的25例残胃癌患者,于发病后3～11月内死亡。76例残胃癌中,原溃疡位于胃部59例(22.3%,59/259),十二指肠球部17例(3.9%,17/434),两部位的残胃癌发生率有显著差异(P<0.05);采用B illrothⅡ式和B illrothⅠ式胃大部切除术患者的术后残胃癌发生率分别为12.7%和7.1%,两者比较有显著差异(P<0.05)。本组残胃癌发病距首次手术的平均时间为15年。结论手术在残胃癌的治疗中具有积极的意义。残胃癌多发生于B illrothⅡ式胃大部切除术后且原发溃疡位于胃部的患者,术后10年以上者发生癌变的危险性较大。

Clinical analysis of 76 cases of gastric stump cancer after subtotal gastrectomy

Objective To observe the treatment and outcomes of gastric stump cancer(GSC) after subtotal gastrectomy,and to analyse the possible related factors for the development of GSC. Methods The clinical data of 693 patients with subtotal gastrectomy were retrospectively analysed.The development,treatment and outcomes of GSC were observed,and the possible factors associated with the development of GSC were analysed. Results Seventy-six cases of GSC emerged in the 693 patients with subtotal gastrectomy.Fifty-one of the 76 cases were perfomed radical operations(n=36) or palliative resection(n=15).No death was found during the perioperative period,and the median survival time was 32.7 and 14.2 months,respectively.Those 25 without surgical management died 3 to 11 months after the development of GSC.Among the 76 cases with GSC,stomach was found as the original site of ulcer in 59(22.3%,59/259),and duodenal bulb in the other 17(3.9%,17/434)(P<0.05).12.7% patients who were perform operations with Billroth II in the subtotal gastrectomy developed GSC,and that was 7.1% for Billroth I(P<0.05).The mean time from the development of the original disease of ulcer to the subtotal gastrectomy was 15 years for the 76 cases with GSC.Conclusion Surgical management plays a positive role in the treatment of GSC.Those with Billroth II in the subtotal gastrectomy and stomach as the site of original disease are more susceptible to GSC and are more likely to develop GSC 10 years after the subtotal gastrectomy.