Incidence and significance of <Emphasis Type="Italic">FLT3</Emphasis>-ITD and <Emphasis Type="Italic">NPM1</Emphasis> mutations in patients with normal karyotype acute myeloid leukaemia期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Incidence and significance of FLT3-ITD and NPM1 mutations in patients with normal karyotype acute myeloid leukaemia

Authors:	K. Haslam N. Chadwick J. Kelly P. Browne E. Vandenberghe C. Flynn E. Conneally S. E. Langabeer

Affiliation:	(1) Cancer Molecular Diagnostics, Central Pathology Laboratory, St. James Hospital, Dublin, Ireland;(2) Department of Haematology, St. James Hospital, Dublin, Ireland;(3) National Centre for Medical Genetics, Our Lady’s Children’s Hospital, Dublin, Ireland

Abstract:	Background Acute myeloid leukaemia (AML) is a heterogeneous clonal disorder of haematopoietic progenitor cells. Approximately half of all adult AML patients have a normal karyotype (NK-AML) and an intermediate risk prognosis.

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