对氧磷酶2基因311Cys／Ser多态性及血脂血糖指标与海南地区阿尔茨海默病的相关性研究

目的探讨对氧磷酶2（PON2）基因311Cys／Ser（C／S）基因多态性及血脂血糖指标与海南地区阿尔茨海默病（AD）的关系。方法用聚合酶链反应．限制性片段长度多态性（PCR．RFLP）分析技术对22例AD患者和31例年龄匹配的健康对照者进行PON2—311Cys／Ser基因多态性及血脂血糖指标的分析。结果AD患者组PON2-311基因频率和等位基因频率与健康对照组之间比较无显著陛差异。总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白（HDL-C）、载脂蛋白A（ApoA）、载脂蛋白B（ApoB）和血糖（Glu）在老年性痴呆症患者和健康对照者问无显著性差异（P〉0．05）。SS基因型人群中低密度脂蛋白（LDL-C）在老年性痴呆症患者和健康对照者间有显著性差异（P〈0．05）。结论海南地区PON2基因C31IS多态性及血脂血糖指标与AD患者没有显著相关性。

The association of the paraoxonase-2 311Cys/Ser polymorphism and blood lipids and blood glucose index with Alzheimer's disease in Hainan

Objective To study the relationship between paraoxonase-2（PON2） gene 311Cys/Ser（C/ S） polymorphism with blood lipids and blood glucose index and Alzheimer＇s disease（AD） in Hainan. Methods Paraoxonase-2 311 Cys/Ser gene polymorphism and blood lipids and blood glucose for 22AD patients and 31 age-matched health controls were analysised by using polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP）. Results The gene frequencies and allele frequencies of the paraoxonase-2 311Cys/Ser in AD were not significantly different from those of control. The levels of total cholesterol （TC）, triglyceride （TG）, high density lipoprotein cholesterol（HDL-C）, apolipoprotein A（Apo A）, apolipoprotein B（Apo B） and blood glucose（Glu） were no significant difference in the case and control group（P〉 0.05）. In the SS genotype, low density lipoprotein cholesterol（LDL-C） was different between the case and control group （P〈0.05）. Conclusion The polymorphism of PON2 C311S gene and blood lipids and blood glucose were not significant associated with AD in Hainan.