Evaluation of Helicobacter pylori infection and other risk factors in patients with benign peptic ulcer disease |
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| Authors: | Depender Kumar Timshina SS Pankaja Himagirish K Rao Vikram Kate |
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| Affiliation: | 1. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania;2. Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania;1. Krembil Neuroscience Centre, Division of Neurology, Toronto Western Hospital, University of Toronto, 399 Bathurst Street, Toronto, Ont. M5T 2S8, Canada;2. Program in Neurosciences and Mental Health, Research Institute, The Hospital for Sick Children, University of Toronto, Toronto, Ont. M5G 1X8, Canada;1. Department of Surgical Sciences, Section of Vascular Surgery, Uppsala University, Uppsala, Sweden;2. Department of Surgical Sciences, Section of Anesthesiology, Uppsala University, Uppsala, Sweden;1. Departamento de Microbiología, Facultad de Ciencias Biológicas, Universidad de Concepción, Concepción, Chile;2. Unidad de Patología Cervical, Hospital las Higueras, Talcahuano, Chile;3. Departamento de Estadística, Facultad de Ciencias Físicas y Matemáticas, Universidad de Concepción, Concepción, Chile;1. Division of Molecular and Clinical Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan;2. Department of Advanced Molecular and Cell Therapy, Kyushu University Hospital, Fukuoka, Japan;3. Division of Pathophysiological and Experimental Pathology, Department of Pathology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan;4. Division of Transgenic Technology, Center for Animal Resources and Development, Kumamoto University, Kumamoto, Japan;5. Division of Cancer Genetics, Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan |
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| Abstract: | ObjectiveTo assess and compare the risk factors in patients with benign gastric and duodenal ulcers and to correlate the prevalence of Helicobacter pylori (H. pylori) infection in benign peptic ulcer disease.MethodsA total of 30 consecutive patients with peptic ulcer disease were included in this study after upper gastrointestinal endoscopy. Their clinical profile and endoscopic findings were noted. Antral biopsies were subjected to histopathological examination and urease test for detection of H. pylori. Results were correlated. The study was cleared by the Institute Research Council and the Ethics committee.ResultsThe male: female ratio was 11:4. Overall, H. pylori infection was prevalent in 93.3% of the patients. Patients who took spicy food had a significantly higher rate of H. pylori positivity (P=0.04). Smoking, alcohol intake and NSAIDs did not affect H. pylori status in patients. There was no significant association between the site of the ulcer and H. pylori infection.ConclusionsBased on our observations we conclude that prevalence of H. pylori infection is similar in duodenal and gastric ulcers and intake of spicy food is a significant risk factor. |
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