大骨节病病区学龄前儿童骨干骺端X线改变调查

目的探讨大骨节病的发病机理及大骨节病病区学龄前儿童骨关节部位X线表现。方法纳入大骨节病病区四川省金川县河西乡乃当村1~6岁学龄前儿童,拍摄手、膝关节X光片,盲法读片。结果全村共22名学龄前儿童,除外2例仍在哺乳、3例外出未归者后,纳入17例,另有3例6~8岁学龄儿童因家长发现其关节肿大也应要求纳入检查。结果发现该20例受检儿童均有尺和/或桡骨、股骨和/或胫骨干骺端X线改变。结论轻型大骨节病病区金川县河西乡乃当村学龄前儿童普遍存在骨干骺端改变,符合"脱碘酶功能障碍假说"关于大骨节病病区低龄儿童可能存在软骨发育障碍的推论。

Changes of Bone on X-ray Photography in Preschool Children in Kashin-Beck Disease Endemic Area

Objective To explore the etiological mechanism of Kashin-Beck disease (KBD) and the changes of bone on X-ray photography in preschool children in the KBD endemic area. Methods Children of 1-6 years old in Naidang village of Jinchuan county, Sichuan province, China were included; and their wrist and knee joints X-ray photos were collected. The photos were blindly diagnosed. Results Of the 22 children aged 1-6 years old in the village, 17 were included and another 3 aged 6-8 years old asked for examination. All children showed changes in bone metaphysis around wrist or/and knee joints based on the results of X-ray examination. Conclusion The 20 children in mild type KBD area show common changes in bone metaphysis This result coincides with our hypothesis that hypoplastic cartilage should occur in the population of preschool children in the KBD endemic area.