喉鳞状细胞癌Paxillin表达的临床意义

目的 探讨喉鳞状细胞癌Paxillin蛋白表达的临床意义。方法 运用免疫组化S-P法检测石蜡包埋喉鳞癌标本74例，以及癌旁正常组织70例，癌旁轻度、中度、重度不典型增生黏膜上皮组织65、69、72例，分析比较Paxillin蛋白表达水平与患者各类临床资料的相关性及其临床意义。结果 喉鳞癌组织Paxillin阳性率明显高于正常组织标本（P〈0．05），不同分化程度癌组织的Paxillin阳性率也存在显著性差异，低分化者阳性率明显高于高和中分化组（P=0．001），伴有颈部淋巴结转移者阳性率明显高于无转移者（P=0．000），而且临床Ⅳ期病例阳性率又明显高于其他各期患者（P=0．000）。结论 Paxillin的阳性表达水平与喉鳞状细胞癌的分化程度、颈淋巴结转移、临床分期有明显相关性，对其病理过程具有一定影响。

Clinical implications of paxillin expressing in laryngeal squamous cell carcinoma

Objective To investigate the clinical implications of paxillin expressing in laryngeal squamous cell carcinoma(LSCC).Methods Included in this study were 74 samples of LSCC,70 samples of paracanceous healthy tissue,and 65,69 and 72 cases of paracanceous dysplastic tissue samples at mild,moderate and severe degrees respectively.The expression of paxillin in them was detected by means of immunohistochemical S-P procedures.Then,comparative analysis was made to explore the association of paxillin expressing with various kinds of clinical data and to see its clinical implications of paxillin.Results The positive expressing rate of paxillin in LSCC was significantly higher than that in healthy tissue samples(P<0.05).Furthermore,such a difference was also seen among the samples with differently differentiating levels,seen with very higher positive expressing rate of paxillin in poorly differentiated cancerous tissues(P<0.001),very higher positive rate among the cases with neck lymph node metastasis(P<0.000),and very higher positive rate among the cases at IV clinical staging(P<0.000).Conclusions There are significant associations of paxillin expressing with differentiating levels,neck metastasis and clinical staging of LSCC,and the activity of paxiiin expression holds significant implications in the developing course of this tumor.