A rare occurrence of trisomy 18 and trisomy 21 in a dizygotic twin pregnancy |
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| Authors: | Harold M. P. Pelikan Emilia K. Bijlsma Willem J. van Wijngaarden |
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| Affiliation: | (1) Department of Obstetrics and Gynaecology, University Hospital Maastricht (AZM), P. O. Box 5800, 6202 AZ Maastricht, The Netherlands;(2) Center for Human and Clinical Genetics, Department of Clinical Genetics, LUMC, University of Leiden, Leiden, The Netherlands;(3) Department of Obstetrics and Gynaecology, Bronovo Hospital, The Hague, The Netherlands |
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| Abstract: | ![]()
Objective Case report of a rare combination of a trisomy 18 and 21 in a dizygotic twin pregnancy in a woman with a history of recurrent miscarriage, a neonatal death, no living offspring and Graves disease. Methods Case report and literature search. Results Only one other report in the literature of a combined trisomy 18 and 21 twin pregnancy was found. Conclusion The combination of a trisomy 18 and 21 in a dizygotic twin pregnancy is very rare. Despite the high frequency and clinical importance of aneuploidy, very little is known about the factors that may modulate meiotic non-disjunction. |
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| Keywords: | Twin pregnancy Trisomy 18 Trisomy 21 Aneuploidy |
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