| 免疫抑制对鼠根尖周炎中IL—1α、TNF—αmRNA表达的影响 |
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| 引用本文： | 梅陵宣,刘正,张濒.免疫抑制对鼠根尖周炎中IL—1α、TNF—αmRNA表达的影响[J].牙体牙髓牙周病学杂志,2001,11(2):92-94. |
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| 作者姓名： | 梅陵宣 刘正 张濒 |
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| 作者单位： | 上海第二医科大学附属第九人民医院, |
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| 摘 要： | 目的：比较免疫抑制鼠和正常鼠根尖周炎中IL-1α、TNF-αmRNA表达，了解免疫抑制对根尖周炎的影响。方法：20只SD大鼠分成实验组（腹腔注射环磷酰胺）和对照组（腹腔注射生理盐水），3周后将实验组和对照组上、下颌磨牙开髓，分别于术后3、7、14、28d取根尖周组织，用RT-PCR方法检测IL-1α和TNF-αmRNA表达，并进行半定量分析。结果：实验组术后7d根尖周组织中即有IL-1α和TNF-αmRNA表达，14d达高峰，28d有所下降；对照组呈与此相似的动态过程，两者间的表达量无明显差别。结论：外周血白细胞减少对根尖周炎中IL-1α表达无明显影响。
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| 关 键 词： | 根尖周炎 免疫抑制 IL－1α TNF－α |
| 文章编号： | 1005-2593(2001)02-0092-03 |
| 修稿时间： | 2000年8月5日 |
Effect of
immuno-suppression on expression of IL-1 |
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| MEI Ling-xuan,LIU Zheng,ZHANG Bin.Effect of
immuno-suppression on expression of IL-1[J].Chinese Journal of Conservative Dentistry,2001,11(2):92-94. |
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| Authors: | MEI Ling-xuan LIU Zheng ZHANG Bin |
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| Abstract: | AIM: To compare the expression of IL-1α and TNF-α m RNA in periapical disease between rats with immuno-suppression and rats without treatment to investigate the effect of immuno-suppression on periapical dis ease. METHODS: Cyclophosphamide, an immuno-suppressant, wa s injected into the abdominal cavity of rats and the expression of IL-1α and TN F-α mRNA was examined with RT-PCR. RESULT:The expression of IL-1α and TNF-α mRNA was detected in periapical tissues at 7th day and formed a pea k at 14th day and slightly decreased at 28th day after the injectio n of the cyclophosphamide. There was no significant difference between the test and control groups. CONCLUSION: Decrease of the perip heral leucocytes has no effect on periapical disease. |
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