| 阿卡波糖片的溶出度考察 |
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| 引用本文： | 谢向阳,许鑫,韩亮,符旭东,陈鹰.阿卡波糖片的溶出度考察[J].中国药师,2011,14(1):76-78. |
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| 作者姓名： | 谢向阳 许鑫 韩亮 符旭东 陈鹰 |
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| 作者单位： | 1. 广州军区武汉总医院,武汉,430070
2. 湖北中医药大学药学院 |
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| 摘 要： | 目的:研究自制与市售阿卡波糖片在不同释放介质中的溶出度曲线,分析体外的释放行为。方法:用HPLC测定制剂的释放度,并对其进行相似因子（f2）比较和释放模型拟合。结果:以拜糖苹、卡博平为参比制剂,自制片在四种溶出条件下,f2值均大于50;释放模型显示药物的溶出机制随着介质的种类不同而不同。结论:自制阿卡波糖片与市售片剂的体外溶出行为相似。
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| 关 键 词： | 阿卡波糖 溶出度 相似因子 |
Study on Dissolution of Acarbose Tablets |
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| Xie Xiangyang,Xu Xin,Han Liang,Fu Xudong,Chen Ying.Study on Dissolution of Acarbose Tablets[J].China Pharmacist,2011,14(1):76-78. |
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| Authors: | Xie Xiangyang Xu Xin Han Liang Fu Xudong Chen Ying |
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| Institution: | Xie Xiangyang~1,Xu Xin~2,Han Liang~1,Fu Xudong~1,Chen Ying~1(1.Wuhan General Hospital of Guangzhou Military Command,Wuhan 430070,China,2.Pharmaceutical School of Hubei University of Traditional Chinese Medicine) |
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| Abstract: | Objective:To study in vitro dissolution profile of three acarbose preparations in different media and analyze their dissolution behavior.Method:The dissolution of acarbose tablets was determined by HPLC,drug release mathematical models were introduced and similarity factor(f_2 value) was compared.Result:Glucobay and kaboping were used as reference preparations,f_2 value of self-prepared tablets was all more than 50 in four different dissolution conditions.The mathematical models showed that the release mech... |
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| Keywords: | Acarbose Dissolution Similarity factor |
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