| 吗替麦考酚酯治疗难治性原发性肾病综合征疗效观察 |
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| 引用本文： | 汤京华,汤婷,方莉,冯曦. 吗替麦考酚酯治疗难治性原发性肾病综合征疗效观察[J]. 中国药师, 2011, 14(1): 104-105 |
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| 作者姓名： | 汤京华 汤婷 方莉 冯曦 |
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| 作者单位： | 南京医科大学附属常州第二人民医院肾内科,江苏常州,213003 |
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| 摘 要： | 目的：观察吗替麦考酚酯（MMF）治疗难治性原发性肾病综合征的疗效及安全性。方法：22例原发性难治性肾病综合征患者，予以MMF治疗，初始剂量1．5-2．0g·d^-1，3-6个月后逐渐减量，疗程6个月；同时口服泼尼松片30—60mg·d^-1。治疗前及治疗后3、6个月测定患者的24h尿蛋白定量、血清白蛋白、血常规、尿常规、肝肾功能，观察记录不良反应。结果：经治疗患者尿蛋白定量下降，血清白蛋白水平上升（P〈0．01）；治疗前后肾功能无明显变化；不良反应可以耐受。结论：MMF治疗难治性原发性肾病综合征有效、安全，值得临床推广使用。
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| 关 键 词： | 吗替麦考酚酯 难治性肾病综合征 泼尼松 |
Effect of Mycophenolate Mofetil in Treatement of Refractory Nephropathy Syndrome |
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| Tang Jinghua,Tang Ting,Fang Li,Feng Xi. Effect of Mycophenolate Mofetil in Treatement of Refractory Nephropathy Syndrome[J]. China Pharmacist, 2011, 14(1): 104-105 |
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| Authors: | Tang Jinghua Tang Ting Fang Li Feng Xi |
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| Affiliation: | Tang Jinghua,Tang Ting,Fang Li,Feng Xi(Department of Nephrology,Second Hospital of Changzhou Affiliated to Nanjing Medical University,Jiangsu Changzhou 213003,China) |
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| Abstract: | Objective:To observe the efficacy and safety of mycophenolate Mofetil(MMF) in treatment of refractory nephropathy syndrome.Method:Twenty-two patients with refractory nephropathy syndrome were treated by MMF.The clinical data was observed in the 12th week and 24th week.Result:The proteinuria of the patients decreased while serum albumin increased significantly(P<0.01) after the patients received MMF treatment and serious side effect was not observed.Conclusion:MMF is an effective and safe drug in treatment o... |
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| Keywords: | Mycophenolate mofetil Refractory nephropathy syndrome Prednisolone |
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