| Dickkopf（DKK-1）在骨肉瘤组织中的表达及临床意义 |
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| 引用本文： | 杜振广,徐绍年. Dickkopf（DKK-1）在骨肉瘤组织中的表达及临床意义[J]. 中国骨肿瘤骨病, 2009, 8(2): 70-72. DOI: 10.3969/j.issn.1671-1971.2009.04.002 |
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| 作者姓名： | 杜振广 徐绍年 |
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| 作者单位： | 辽宁省人民医院骨肿瘤科,沈阳,110016 |
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| 摘 要： | 目的研究DKK-1在骨肉瘤中的表达情况，探讨其与临床病理及预后的关系。方法S-P免疫组织化学染色法对74例骨肉瘤DKK-1蛋白的表达进行检测，并对其与骨肉瘤临床病理及预后的关系进行统计学分析。结果74例骨肉瘤标本中58例为阳性，总阳性率为78．4％（58／74）。DKK-1的表达在不同年龄、性别、骨肉瘤亚型中无显著性差异。Enneking分期Ⅰ—ⅡA与ⅡB—Ⅲ之间，肿瘤DKK-1表达率有显著性差异（P〈0．05）。结论DKK-1在骨肉瘤组织中有较高比例的表达，并与肿瘤的外科分期密切相关。
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| 关 键 词： | 骨肉瘤 DKK-1 免疫组织化学 |
Expression and clinical significance of DKK-1 in osteosarcoma |
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| DU Zhenguang,XU Shaonian. Expression and clinical significance of DKK-1 in osteosarcoma[J]. Chinse Journal Of Bone Tumor And Bone Disease, 2009, 8(2): 70-72. DOI: 10.3969/j.issn.1671-1971.2009.04.002 |
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| Authors: | DU Zhenguang XU Shaonian |
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| Affiliation: | .( Department of Orthopedic Surgery, Liaoning Province Hospital, Liaoning Shenyang 110016 China) |
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| Abstract: | Objective To investigate the expression of DKK-1 in osteosareoma and its relationship to osteosarcoma clinical pathology and prognosis. Methods The expression of DKK-1 protein in 74 osteosarcoma specimens was evaluated by S-P immunohistochemistry, and statistical analysis was performed, Results The positive expression rate of DKK-1 protein in osteosarcoma was 78.4%（58/74）. There was a significant difference between the expression of DKK-1 in patients with different age, sex and osteosarcoma subtypes, whilst not in Enneking surgical staging. Its expression rate in enneking surgical stagingⅠ-ⅡA was significantly lower than that in stagingⅡB-Ⅲ （P〈0.05）. Conclusions There was a higher level of DKK-1 expression in osteosarcoma tissue, which is closely related to tumor surgical staging. |
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| Keywords: | DKK-1 |
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