Abstract: | Objective To evaluate the clinical efficacy of transcatheter arterial chemoembolization (TACE) combined with rivatinib and microwave ablation (MWA) in the treatment of advanced large hepatocellular carcinoma.Methods Select 73 patients with advanced large hepatocellular carcinoma admitted to the Peking Union Medical College, Chinese Academy of Medical Sciences and the Second Hospital of Beijing from January 2018 to December 2021. 36 patients were treated with TACE combined with rivatinib and MWA, were set as observation group; 37 patients were treated with TACE combined with rivatinib were set as the control group. The short-term efficacy, progression-free survival, total survival rate and complications of the two groups were compared.Results The effective remission rates of the disease in the observation group and the control group after 4 months were 72.2% and 40.5% respectively, with a significant difference (P<0.05). The median progression-free survival was 18 months in the observation group and 10 months in the control group. There was a significant difference between the two groups (P<0.05). The total survival rates at 6, 12, 18, 24 and 36 months in the observation group were 97.2%, 82.7%, 70.1%, 54.1% and 22.3%, respectively, and the total survival rates at 6, 12, 18, 24 and 36 months in the control group were 94.6%, 66.9%, 35.4%, 32.2% and 9.7% respectively. The total survival rate of the observation group was significantly higher than that of the control group (P<0.05). There was no significant difference in the incidence of postoperative complications between the two groups (P>0.05).Conclusion TACE combined with rivatinib combined with MWA in the treatment of middle and advanced large liver cancer can strengthen the curative effect and effectively prolong the survival time of patients. |