Evaluation of diuretic and laxative activity of hydro-alcoholic extract of Desmostachya bipinnata (L.) Stapf in rats |
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| Affiliation: | 1. Department of Biological Sciences, Indian Institute of Science Education and Research (IISER), Bhopal-462023, Madhya Pradesh, India;2. Department of Pharmacology, Faculty of Pharmacy, Bharat Institute of Technology, Hyderabad-501510, Andhra Pradesh, India;1. Department of Hepatology, Qilu Hospital of Shandong University, Institute of Shandong University, Wenhuaxi Road 107#, Shandong, Jinan 250012, China;2. Department of Infectious Diseases, Qingdao Women and Children Hospital, Qingdao 266034 Shandong, China;3. Institute of Hepatology, Shandong University, 250012 Shandong, Jinan, China;1. The Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, the College of Life Sciences, Northwest University, No. 229 Taibai North Road, Xi׳an, Shaanxi 710069, PR China;2. School of Chinese Materia Medica, Beijing University of Chinese Medicine, No. 11 North Third Ring Road, Beijing 100029, PR China;1. Sri Paramakalyani College, Manonmaniam Sundaranar University, Alwarkurichi 627412, India;2. Sri Paramakalyani Centre of Excellence in Environmental Sciences, Manonmaniam Sundaranar University, Alwarkurichi 627412, India;3. Department of Physics and Astronomy, College of Science, King Saud University, Riyadh 11451, Saudi Arabia;4. Chemical Industry Research Institution, University of Ulsan, Ulsan 44776, South Korea |
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| Abstract: | ![]()
ObjectiveIn continuation to the growing evidence for therapeutical potential of Desmostachya bipinnata (Linn) Stapf, the current pharmacological study was carried out to evaluate the diuretic and laxative activity of its hydro-alcoholic extract in rats.MethodsThe hydro-alcoholic extract of D. bipinnata whole plant was prepared by using Soxhlet extractor and subjected to analysis by standard preliminary phytochemical tests. Evaluation of both diuretic and laxative activity was carried out using standard methods as reported earlier. Frusemide (20 mg/kg) was served as positive control for diuretic activity and sennosides (10 mg/kg) served as negative control for laxative activity.ResultsThe hydro-alcoholic extract showed significant diuretic activity and was found to be the most potent in increasing the urinary output at 500 mg/kg when the effect was compared with that of the standard frusemide (P<0.01). Moreover, this extract was found to be most effective in increasing urinary electrolyte concentration (Na+, K+, and Cl−) at both doses tested. Whereas the results for laxative activity showed minimal increase of feces output at the dose of 500 mg/kg and the increase was negligible when compared with that of the standard drug sennosides.ConclusionAltogether, the above significant findings validate and support its folkloric diuretic use and lend pharmacological credence to the ethno-medical use of this plant in traditional system of medicine, which demands further studies to investigate its active constituents, as well as its use and safety. |
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| Keywords: | plant extracts bioassay diuretic laxative frusemide sennosides ethnomedicine rats |
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