Safety of 5 kHz tACS |
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| Affiliation: | 1. Experimental Psychology Lab, Department of Psychology, Cluster for Excellence “Hearing4all”, European Medical School, Faculty for Medicine and Health Sciences, University of Oldenburg, 26129 Oldenburg, Germany;2. Research Center Neurosensory Science, University of Oldenburg, 26111 Oldenburg, Germany;3. Department of Psychology, University of Oslo, 0373 Oslo, Norway;4. The Mind Research Network, Albuquerque, NM 87106, USA |
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| Abstract: | ![]()
BackgroundSinusoidal transcranial alternating current stimulation (tACS) at 5 kHz applied for 10 min at 1 mA intensity over the hand area of the primary motor cortex (M1) results in sustained changes in cortical excitability as previously demonstrated.ObjectiveHere we have assessed safety aspects of this stimulation method by measuring neuron-specific enolase (NSE) levels, examining electroencephalogram (EEG) traces and analyzing anatomical data by using magnetic resonance imaging (MRI).MethodsAltogether 18 healthy volunteers participated in the study. tACS was applied at 5 kHz for a duration of 10 min over the left M1 at an intensity of 1 mA.ResultsAfter stimulation no significant changes were detected in NSE levels, no structural alterations were observed in the anatomical scans and no pathological changes were found in the EEG recordings.ConclusionsOur data imply that the application of tACS is safe at least within these parameters and with these applied protocols. |
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| Keywords: | Alternating current stimulation Side effects M1 Human |
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