Gastric antisecretory and cytoprotective effects of hydroalcoholic extracts of Plumeria alba Linn. leaves in rats |
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| Affiliation: | 1. Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra 136119, India;2. All India Institute of Medical Sciences, New Delhi 110029, India;1. Laboratório de Farmacologia e Química Medicinal, Departamento de Química Biológica, Universidade Regional do Cariri, CE 63100-000, Brazil;2. Campus São Gabriel, Universidade Federal do Pampa, São Gabriel, Rio Grande do Sul 97300-000, Brazil;3. Laboratório de Pesquisa em Fitoquímica, Departamento de Farmácia Industrial, Universidade Federal de Santa Maria, Prédio 26, Sala 1115, Santa Maria, CEP 97105-900, Brazil;4. Departamento de Química, Programa de Pós-Graduação em Bioquímica Toxicológica, Universidade Federal de Santa Maria, Santa Maria, RS 97105-900, Brazil;5. Departamento de Bioquímica, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS CEP 90035-003, Brazil;1. Department of Pharmacognosy, Faculty of Pharmacy, University of Lagos, Nigeria;2. School of Chemistry, University of KwaZulu-Natal (Westville Campus), Durban, 4000, South Africa;1. Clinical Research Unit (Homeopathy), Siliguri 734006, Darjeeling, West Bengal, India; under Central Council for Research in Homeopathy, Government of India;2. Department of Pathology and Microbiology, Mahesh Bhattacharyya Homeopathic Medical College and Hospital, Howrah 711104, West Bengal, India;3. Department of Organon of Medicine and Homeopathic Philosophy, D N De Homeopathic Medical College and Hospital, Kolkata 700046, West Bengal, India;4. Department of Organon of Medicine and Homeopathic Philosophy, Midnapore Homeopathic Medical College and Hospital, Midnapore (West) 721101, West Bengal, India;5. Department of Organon of Medicine and Homeopathic Philosophy, Calcutta Homeopathic Medical College and Hospital, Kolkata 700009, West Bengal, India;6. Department of Community Medicine, Medical College of Kolkata, Kolkata 700079, West Bengal, India;1. Postgraduate Studies in Health Sciences, Faculty of Medicine, Federal University of Mato Grosso (UFMT), 78060-900 Cuiabá, MT, Brazil;2. Department of Basic Health Sciences, Faculty of Medicine, Federal University of Mato Grosso (UFMT), 78060-900 Cuiabá, MT, Brazil |
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| Abstract: | ![]()
OBJECTIVE:This study was conducted to evaluate the antiulcerogenic property of hydroalcoholic extract obtained from the leaves of Plumeria alba Linn.METHODS:Antiulcer assays were performed using the protocols of ulcer induced by nonsteroidal anti-inflammatory drugs,ethanol and pylorus ligation.The hydroalcoholic extract(HAPA),and various fractions of HAPA like,n-hexane extract(HPA),ethyl acetate extract(EAPA) and n-butanol extract(BPA) were administered at doses of 200 and 400 mg/kg for HAPA and 100 and 200 mg/kg for fractions of extracts.Parameters of gastric secretion(volume,pH,total protein,and free and total acidity) were determined by the pylorus ligation model.Parameters like aspartate aminotransferase and alanine aminotransferase were also determined in ethanolinduced ulcer model.To determine the mechanism of action,role of nitric oxide was also evaluated.RESULTS:EAPA and BPA(100 and 200 mg/kg,p.o.) showed gastric ulcer-healing effect in indomethacin-induced ulcer model,while HAPA(200 mg/kg) and HPA showed no significant antiulcer effect.Both EAPA and BPA showed gastric cytoprotective effect in ethanol-induced gastric ulcer and inhibited gastric secretion in pylorus-ligated rats.CONCLUSION:The results of the present study show that some hydroalcoholic extract of Plumeria alba L.displays antiulcer activity,as demonstrated by the significant inhibition of ulcer formation induced by different models,which is consistent with the literature report in folk medicine. |
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| Keywords: | anti-ulcer agents plant extracts rats |
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