Supraorbital Stimulation Does Not Induce an Antidepressant-like Response in Rats |
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| Affiliation: | 1. Division of Biokinesiology and Physical Therapy, University of Southern California, Los Angeles, California, United States;2. School and Graduate Institute of Physical Therapy, National Taiwan University, Taipei, Taiwan;1. Department of Psychiatry, National Defense Medical College, Tokorozawa, Saitama, Japan;2. Department of Neurosurgery, Jichi Medical School, Shimotsuke, Tochigi, Japan;3. Division of Behavioral Sciences, National Defense Medical College, Tokorozawa, Saitama, Japan;4. Military Medicine Research Unit, Test and Evaluation Command, Japan Ground Self Defense Force, Setagaya, Tokyo, Japan |
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| Abstract: | ![]()
BackgroundNeuromodulation therapies are currently being investigated as potential treatments for depression. One of these treatments involves the stimulation of supraorbital branches of the trigeminal nerve.ObjectiveTo show that supraorbital stimulation is effective in preclinical models.MethodsRats were given supraorbital stimulation at different settings in the forced swim test (FST) and open field.ResultsSupraorbital stimulation did not induce an antidepressant-like response in rats undergoing the FST. This is in contrast to other neuromodulation treatments, such as deep brain stimulation, vagus nerve stimulation and electroconvulsive therapy, which are all effective in this paradigm.ConclusionsSupraorbital stimulation was ineffective in rats undergoing the FST. Such findings do not invalidate results of recent clinical trials. |
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| Keywords: | Supraorbital nerve Trigeminal nerve Stimulation Depression Rats |
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