|
|||||
|
|
| 肝癌病人的氮－乙酰化酶多态性研究 | |
| 引用本文： | 凌敏，文跃进，徐玉辉，金进兴，周治平，茅林梅，陈安天，薛寿征. 肝癌病人的氮－乙酰化酶多态性研究[J]. 癌变．畸变．突变, 1994, 0(6) |
| 作者姓名： | 凌敏，文跃进，徐玉辉，金进兴，周治平，茅林梅，陈安天，薛寿征 |
| 作者单位： | 江苏省职业病防治研究所，江苏省人民医院，启东市卫生防疫站，上海医科大学 |
| 摘 要： | 代谢酶多态性决定着对致癌化学物的易感性和耐受性，是肿瘤发生的遗传先决影响因素之一。本文首报了肝癌病人中氮－乙酰化酶多态性研究。４６例肝癌病人中１９例为慢型（４１．３％）；而当地的代表人群，中学生１１４４人中２３２为慢型（２０．７％）；基因频率分别为：０．６４２７及０．４５０３，两者之间有显著差异。从中推算的乙酰化酶慢型者的肝癌的相对危险度为２．７７（１．５５－４．９６）。本调研为肝癌的病因学研究提供了新的线索。 |
| 关 键 词： | 氮－乙酰化酶多态，肿瘤遗传先决影响因素，肝癌 |
STUDY ON THE N-ACETYLTRANSFERASE POLYMORPHISM AMONG PRIMARY LIVER CANCER PATIENTS |
|
| Abstract: | Polymorphism of metabolic enzyme is one of the factors relevant to the susceptibility to environmental chemicals and hereditary predispositional to carcinogenesis.The polymorphism of N-Acetyltransferase among primary livercancers is investigated and reported originally.It was found that 19 among 46 PLC patiepts(41.3%)were slow type of N-AT versus the referring figure 232/1144( 20.7%) in middle school students.Their gene frequencies were calculated as 0.6427 and 0.4503 respectively.The excessive risk of PLC for slow N-AT was2.77(1.55-4.96) with statistical significance.It ls hoped that this report would throw clue into the study of aetiology of PLC. |
| Keywords: | N-acetyltransferase polymorphism genetic predispostion factor for carcinogenesis liver cancer. |
| 本文献已被 CNKI 等数据库收录！ | |