补充叶酸及B族维生素对冠心病患者介入治疗后血管内皮功能的影响

目的 探讨在常规治疗基础上补充叶酸及B族维生素对冠心病患者介入治疗后血管内皮功能的改善作用.方法 选择冠状动脉介入治疗后的冠心病患者80例,在常规治疗基础上按照随机数字表法随机分为两组,对照组40例给予常规治疗,治疗组40例在常规治疗的基础上加服叶酸15 mg/d,维生素B_6 30 mg/d,维生素B_(12)75μg/d.随访6个月,观察两组同型半胱氨酸(Hcy)水平,并以超声测定肱动脉血流介导的舒张功能(FMD)变化来评价血管内皮功能.结果 治疗组与对照组治疗后血浆Hcy分别为(8.62±3.51)、(12.96±4.62)μmol/L,较治疗前的(13.24±5.07)、(13.87±5.13)μmol/L均有下降,且治疗组下降更明显,与对照组治疗后比较差异有统计学意义(P<0.01);治疗组FMD由治疗前(4.22±1.46)%增加至治疗后(8.74±1.51)%,差异有统计学意义(P<0.01).结论 常规治疗能明显改善冠心病患者介入治疗后的血管内皮功能,补充叶酸及B族维生素可以使患者在常规治疗基础上获益更多.

The effects of folk acid and B vitamins supplement on vascular endothelial function in patients of coronary artery disease who undergone interventional therapy

Objective To evaluate the improvement of endothelial function by folic acid and B vitamins supplement in patients of coronary artery disease who undergone interventional therapy.Methods Eighty patients of coronary artery disease who undergone interventional therapy were divided into two groups:control group(40 cases,routine treatment)and treatment group(the others,with routine treatment plus orally taken folic acid and B vitamins,folic acid 15mg/d,vitamin B_(12)75μg/d,vitamin B_6 30mg/d,for 6 months).Plasma homocystine (Hcy)was measured by fluorescence polarization immunoassay and flow-mediated dilation(FMD)of the brachial artery was assessed by high resolution ultrasound before and after 6 months.Results After treatment,the levels of Hcy decreased obviously in treatment group[(8.62±3.51)μmol/L]than that in control group[(12.96±4.62)μmol/L](P<0.01).The FMD was increased significantly in treatment group[(4.22±1.46)%vs (8.74±1.51)%,P<0.01].Conclusions Routine treatment,including aspirin and stafins,significantly improves endothehal function in patients with coronary artery disease.Folic acid and B vitamins supplement may exert beneficial effects on patients with coronary artery disease.