| 醒髓汤对大鼠脊髓损伤组织一氧化氮含量影响的实验研究 |
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| 引用本文： | 谭龙旺,杨利学,杨毓华,李小群,王晓玲,孙智平.醒髓汤对大鼠脊髓损伤组织一氧化氮含量影响的实验研究[J].中国中医骨伤科杂志,2008,16(11):29-31. |
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| 作者姓名： | 谭龙旺 杨利学 杨毓华 李小群 王晓玲 孙智平 |
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| 作者单位： | 陕西中医学院附属医院骨科,陕西咸阳712000 |
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| 摘 要： | 目的：观察醒髓汤（XST）对大鼠脊髓损伤后组织一氧化氮含量变化的影响，探讨XST在脊髓继发性损伤中的作用。方法：SD大鼠60只随机分组，改良的ALLEN’S法制成脊髓损伤模型，XST治疗7天，另设强的松龙对照组、模型组及空白组，观察伤后1h、8h、24h、3天、7天脊髓NO含量变化。结果：脊髓损伤后NO含量立即显著升高，至8h达到高峰，而后逐渐下降，醒髓汤组NO含量明显降低，与其它纽相比差异有统计学意义（P〈0．01）。结论：脊髓损伤后NO的升高是导致脊髓继发性损伤的重要因素，而醒髓汤能明显抑制脊髓损伤后组织NO含量的升高，改善脊髓损伤后的神经功能。
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| 关 键 词： | 脊髓损伤/中医疗法 一氧化氮 醒髓汤 |
The Effect of Xingsui Decoction on Nitric Oxide in Spinal Cord Injury Tissue |
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| TAN Longwang YANG Lixue YANG Yuhua LI Xiaoqun WANG Xiaoling SUN Zhiping.The Effect of Xingsui Decoction on Nitric Oxide in Spinal Cord Injury Tissue[J].Chinese Journal of Traditional Medical Traumatology & Orthopeics,2008,16(11):29-31. |
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| Authors: | TAN Longwang YANG Lixue YANG Yuhua LI Xiaoqun WANG Xiaoling SUN Zhiping |
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| Institution: | TAN Longwang1 YANG Lixue1 YANG Yuhua1 LI Xiaoqun1 WANG Xiaoling1 SUN Zhiping1Department of Spinal Orthopaedics,Affiliated Hospital of Shaanxi University of Traditional Chinese Medicine,Xianyang 712000,China |
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| Abstract: | Objective:To investigate the effect of Xingsui Decoction (XD) on the change of nitric oxide (NO) content in experimental spinal cord injury (SCI) rats. Methods:The models were established by improved Allent's methods. All rats were divided into SD group,prednisolone group,model group and control group. The NO content in injured spinal was observed at 1st hour,8th hour,3rd day and 7th day. Results:A significant increase of NO was found immediately after SCI. The NO content was highest at 8th hour,and then dr... |
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| Keywords: | Spinal cord injury Therapy with traditional Chinese medicine Nitric oxide Xingsui Decoction |
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