PET imaging of hepatocellular carcinoma with 18F-fluoroethylcholine and 11C-choline |
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| Authors: | Jeffrey A. Kolthammer David J. Corn Nathan Tenley Chunying Wu Haibin Tian Yanming Wang Zhenghong Lee |
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| Affiliation: | (1) Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-7207, USA;(2) Nuclear Medicine Division, Department of Radiology, University Hospitals Case Medical Center, 11100 Euclid Avenue, Cleveland, OH 44106, USA |
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| Abstract: | Purpose Choline-based radiotracers have been studied for PET imaging of hepatocellular carcinoma (HCC). Using an 18F-labeled choline analog, instead of the 11C-labeled native choline, would facilitate its widespread use in the clinic. In this study, PET with 18F-fluoroethylcholine (FEC) and 11C-choline (CHOL) were compared using an animal model of HCC. The effects of fasting on the performance of choline-based tracers were also investigated. |
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