菊苣有效组分对高甘油三酯和高尿酸血症并高血糖大鼠脂代谢的影响

目的：观察菊苣有效组分对高甘油三酯（triglyceride,TG）并高尿酸（uric acid,UA）血症和高血糖（glucose,GLU）大鼠脂代谢的影响,并探讨其作用机制。方法：通过喂饲高果糖食饵21d诱发大鼠高甘油三酯并高尿酸血症和高血糖模型后,开始给药治疗,连续35d,观察3个不同剂量的菊苣有效组分对TG、UA、GLU及与脂代谢相关的代谢产物游离脂肪酸（freefatty acids,FFA）和代谢酶脂肪酸合成酶（fatty acid synthetase,FAS）、肝脂酶（hepatic lipase,HL）及脂蛋白脂酶（lipoproteinlipase,LPL）的影响。结果：造模21d,高果糖模型大鼠血清TG、UA、GLU水平较正常对照组明显升高;给药35d,模型组肝脏FAS活性、血清FFA水平显著升高（P〈0.01）;肝脏HL活性显著降低（P〈0.01）,心肌LPL活性的差异无统计学意义。菊苣有效组分可显著降低模型大鼠血清TG、UA、GLU、FFA水平和FAS活性,并显著升高LPL和HL活性。结论：菊苣有效组分可明显降低由高果糖引发的血清TG、UA、GLU升高,其作用机制可能是通过降低肝脏FAS活性和血清FFA水平,并升高心肌LPL和肝脏HL活性来达到综合调节脂、糖、尿酸交互紊乱作用的。

Effects of active component in Cichorii on lipid metabolism of rat with hypertriglyceridemia complicated by hyperuricemia and hyperglycemia

OBJECTIVE: To observe the effect of active component in Cichorii (N3) on lipid metabolism of rat with hypertriglyceridemia complicated by hyperuricemia and hyperglycemia. METHODS: Hypertriglyceridemia complicated by hyperuricemia and hyperglycemia was induced in rats by feeding a kind of feedstuff containing high fructose for 21 days. Then three different doses of N3 were administered continuously to the rats for 35 days. The effects of N3 on lipid metabolism were observed by determining the levels of serum triglyceride (TG), uric acid (UA), glucose (GLU) and free fatty acids (FFA) and the activities of fatty acid synthetase (FAS) and hepatic lipase (HL) from the liver and lipoprotein lipase (LPL) from the heart. RESULTS: Twenty-one days after feeding a high-fructose diet, the levels of serum UA, TG and GLU in the untreated group were significantly higher than those of the normal control group. Thirty-five days after administering N3, there was no statistical difference in serum TG and heart LPL activity between the untreated group and the normal control group, while liver FAS activity, serum FFA level and liver HL activity in the untreated group were significantly higher than those in the normal control group. Different doses of N3 treated rats all showed a decrease of TG, UA and GLU levels. N3 could decrease FAS activity and FFA level, and increase LPL and HL activities significantly. CONCLUSION: N3 in Cichorii may regulate the lipid metabolism of the rats with hypertriglyceridemia complicated by hyperuricemia and hyperglycemia by decreasing FAS activity and FFA level, and increasing LPL and HL activities.