| 阿霉素肾病大鼠肾小管基质金属蛋白酶-2、金属蛋白酶抑制剂-2的免疫组织化学观察 |
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| 引用本文： | 李广波,林瑞霞,杨青,唐雪栋.阿霉素肾病大鼠肾小管基质金属蛋白酶-2、金属蛋白酶抑制剂-2的免疫组织化学观察[J].实用医学杂志,2008,24(4):522-525. |
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| 作者姓名： | 李广波 林瑞霞 杨青 唐雪栋 |
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| 作者单位： | 温州医学院附属育英儿童医院肾内科,325027 |
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| 基金项目： | 浙江省教育厅基金资助项目(编号:20061807) |
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| 摘 要： | 目的:探讨基质金属蛋白酶-2(matrix metalloproteinases-2,MMP-2)和金属蛋白酶抑制剂-2(tissue inhibitor of metalloproteinase-2,TIMP-2)在阿霉素肾病大鼠肾小管中的作用。方法:采用大鼠尾静脉单剂量注射阿霉素7.5mg/kg建立阿霉素肾病模型,免疫组织化学检测正常对照组、肾病模型组肾组织MMP-2及TIMP-2的表达变化。结果:肾病模型组大鼠肾小管上皮细胞MMP-2和TIMP-2的表达明显下降,与正常对照组相比差异显著(P<0.01)。结论:MMP-2和TIMP-2在阿霉素肾病的发病过程中可能起重要的作用。
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| 关 键 词： | 肾病 明胶酶A 纤维化 组织金属蛋白酶抑制剂 |
| 修稿时间： | 2007年8月20日 |
Expressiom of MMP-2 and TIMP-2 in renal tubule in rats with adriamycin-induced nephropathy |
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| LI Guang-bo,LIN Rui-xia,YANG Qing,TANG Xue-dong.Expressiom of MMP-2 and TIMP-2 in renal tubule in rats with adriamycin-induced nephropathy[J].The Journal of Practical Medicine,2008,24(4):522-525. |
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| Authors: | LI Guang-bo LIN Rui-xia YANG Qing TANG Xue-dong |
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| Abstract: | Objective To explore the roles of MMP-2 and TIMP-2 in the pathogenesis of adriamycin-induced nephropathy in rats. Methods The rat model of nephropathy was established by an injection of adriamycin at a dose of 7.5 mg/kg via the tail vein. The expressions of MMP-2 and TIMP-2 in the renal epithelial cells in the normal control tubules and the diseased tubules were examined by immunohistochemistry. Results The expressions of MMP-2 and TIMP-2 in the diseased tubules were significantly declined than those in the normal tubules (P < 0. 01). Conclusion MMP-2 and TIMP-2 may play an important role in the pathogenesis of adriamycin-induced nephropathy. |
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| Keywords: | Nephrosis Gelatinase A Fibrosis Tissue inhibitor of metalloproteinase |
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