银杏内酯类合成物F抗血小板激活因子和组织胺的实验研究

目的：研究银杏内酯类化合物Ｆ（简称药物Ｆ）同时拮抗组织胺（ＨＡ）和血小板激活因子（ＰＡＦ）的作用。方法：测定离体豚鼠肺组织的收缩率以及用药物Ｆ后的致敏豚鼠肺功能的变化。结果：（１）加入药物Ｆ后离体豚鼠的气管条和肺条对ＨＡ的收缩率分别由（５０．９７±１６．００）％和（５４．２４±１２．１７）％降至（２１．６９±３．８５）％和（２２．９７±１７．７８）％（Ｐ〈０．０５）；（２）药物Ｆ保护后，离体豚鼠肺

Experimental Study on Effect of Antagonizing Platelet-Activating Factor and Histamine of Synthetic Ginkgolide F in Guinea-Pigs

OBJECTIVE: To investigate the antagonizing effect of synthetic Ginkgolide F (SGF) on platelet-activating factor (PAF) and histamine (HA) in guinea-pigs. METHODS: The contraction rate of isolated lung tissue of guinea-pig and the change of pulmonary function of sensitized guinea-pig after SGF treatment were examined. RESULTS: (1) The contraction rate of guinea-pigs' isolated trachea and lung strip induced by HA reduced from (50.97 +/- 16.00)% and (54.24 +/- 12.17)% to (21.69 +/- 3.85)% and (22.97 +/- 17.78)% after SGF treatment (P < 0.05). (2) PAF induced relative contraction of isolated guinea-pig lung strip was reduced from (89.49 +/- 16.00)% to (46.21 +/- 14.23)% in presence of SGF (P < 0.05). (3) The pulmonary function of sensitized animal had a tendency of being improved by SGF. CONCLUSION: SGF can antagonize the contraction of isolated lung tissue induced by HA or PAF in vitro, and has a tendency to improve the pulmonary function of sensitized guinea-pig, therefore, it may be a promising drug in treatment of bronchial asthma.