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| 高原缺氧对兔视网膜Nogo表达的影响 | |
| 引用本文： | 燕振国,秦萍瑛,李耀宇. 高原缺氧对兔视网膜Nogo表达的影响[J]. 国际眼科杂志, 2008, 8(2): 258-260 |
| 作者姓名： | 燕振国 秦萍瑛 李耀宇 |
| 作者单位： | 1. 兰州军区兰州总医院眼科,中国甘肃省兰州市,730050 2. 兰州大学临床医学院,中国甘肃省兰州市,730000 3. 北京军区总医院眼科,中国北京市,100700 |
| 基金项目： | 中国国家自然科学基金面上项目(No30471856)，中国甘肃省科技攻关项目(No2GS054-A43-014-15)~~ |
| 摘 要： | 目的:观察在高原环境下Nogo在北京青紫蓝兔视网膜中的表达和分布。方法:北京青紫蓝兔24只随机分为实验组20只,对照组4只,分别喂养于高原环境和亚高原环境中1,3,7,10,14d取出兔眼球,制成蜡片,应用免疫组化的方法检测视网膜中Nogo的表达及分布。结果:在高原环境下Nogo在兔视网膜中的表达增多,7d达到高峰,持续到10,14d下降,与对照组比较,差异有统计学意义。结论:在高原环境下,Nogo在视网膜急性缺血缺氧损伤可能发挥了重要作用。 |
| 关 键 词： | 视网膜 勿动蛋白 免疫组化 |
| 收稿时间： | 2007-11-28 |
| 修稿时间： | 2008-01-08 |
Expression and distribution of Nogo in retina of adult rabbit on the plateau |
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| Zhen-Guo Yan,Ping-Ying Qin,Yao-Yu Li. Expression and distribution of Nogo in retina of adult rabbit on the plateau[J]. International Eye Science, 2008, 8(2): 258-260 | |
| Authors: | Zhen-Guo Yan Ping-Ying Qin Yao-Yu Li |
| Affiliation: | 1Department of Ophthalmolgy,Lanzhou General Hospital of Lanzhou Military Command of Chinese PLA,Lanzhou 730050,Gansu Province,China;2Clinical Medical School,Lanzhou University,Lanzhou 730000,Gansu Province,China;3Department of Ophthalmology,General Hospital of Beijing Military Command of Chinese PLA,Beijing 100700,China |
| Abstract: | AIM:To investigate the expression and distribution of Nogo in retina of adult rabbit in the plateau environment.METHODS:Twenty-four rabbits were divided into two groups:twenty of them belonged to experiment group;four of them were in control group.The rabbits were fed in the plateau and sub-plateau environment respectively.On day 1,3,7,10 and 14,the eyes of four adult rabbits were removed respectively.Meanwhile,paraffin retinal slices were made and the expression and distribution of Nogo in the retina was examined by immunohistochemistry.RESULTS:Our data showed that the experimental expression of Nogo increased in retina of adult rabbits in the plateau environment.The highest Nogo value was found on day 7,and persisted till day 10.On day 14 the value of Nogo decreased.There was statistically significant difference between experiment group and control group at 1,3,7,10,14 days with respect to Nogo absorption values.CONCLUSION:It may be of an important effect of Nogo in acute retinal ischemia and hypoxia injuries of adult rabbit in the plateau environment. |
| Keywords: | retina Nogo immunohistochemistry pla-teau |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |