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| E-钙粘素在大鼠阿霉素肾病模型中的表达及其意义 | |
| 引用本文： | 蒋雅红,贺德刚,陶林,赵瑾,杨晓萍. E-钙粘素在大鼠阿霉素肾病模型中的表达及其意义[J]. 临床和实验医学杂志, 2011, 10(5): 321-323 |
| 作者姓名： | 蒋雅红 贺德刚 陶林 赵瑾 杨晓萍 |
| 作者单位： | 1. 新疆石河子大学医学院,新疆,石河子,832002 2. 新疆石河子大学医学院附属第一医院肾病科,新疆,石河子,832003 3. 新疆石河子大学医学院病理科,新疆,石河子,832002 |
| 摘 要： | 目的动态观察E-钙粘素(E-cadherin)在大鼠阿霉素肾病模型中肾小球内的表达,探讨其变化在肾小球疾病中的作用。方法采用大鼠尾静脉单剂量注射阿霉素(浓度2 mg/ml,剂量7.5 mg/kg)建立阿霉素肾病模型,生化检测白蛋白变化,尿液检测24 h尿蛋白定量,光镜下观察肾小球形态学改变,免疫组化检测肾组织E-cadherin和纤维连接蛋白(FN)的表达。结果阿霉素肾病组大鼠肾脏肾小球形态于第4周时出现微小病变,第8周时为局灶阶段性硬化;并且肾病组大鼠均出现大量蛋白尿、低蛋白血症,肾病组与对照组相比,差异具有显著性(P<0.01);E-cadherin在肾小球足细胞的表达随着肾小球病变的加重而逐渐减少;FN在肾小球内的表达随着肾小球病变的加重而逐渐增加;E-cadherin和FN在肾组织内的表达呈负相关(r=0.926,P<0.001)。结论阿霉素肾病组大鼠肾小球E-cadherin表达减少和FN表达增加在不同阶段表达的变化可能参与了肾小球硬化的发生发展过程。 |
| 关 键 词： | 阿霉素肾病 大鼠 动物模型 E-钙粘素 纤维连接蛋白 |
The significance of expression of E-cadherin in rat models with adriamycin-induced nephropathy. |
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| JIANG Ya-hong,HE De-gang,TAO Lin,et al.. The significance of expression of E-cadherin in rat models with adriamycin-induced nephropathy.[J]. Journal of Clinical and Experimental Medicine, 2011, 10(5): 321-323 | |
| Authors: | JIANG Ya-hong HE De-gang TAO Lin et al. |
| Affiliation: | JIANG Ya-hong1,HE De-gang2,TAO Lin3,et al.Shihezi University School of Medicine,Shihezi Xinjiang 832002,China,2 Nephrology,The First Hospital Affiliated of Shihezi University School of Medicine,Shihezi Xinjiang 832003,3 Department of Pathology,Shihezi University School of Medicine,Shiezi Xinjiang 832002,China. |
| Abstract: | Objective To study the significance of expression of E-cadherin in glomeruli of rat models with adriamycin-induced nephropathy,and to explore its role in pathogenesis of glomerular diseases.Methods The rat model of nephropathy was established by injection of adriamycin(with concentration of 2mg/ml and dosage of 7.5 mg/kg) through their tail vein.The serum levels of albumin were determined by biochemical method,and the quantitative determination of protein was examined with 24 hours urine.The expressions of ... |
| Keywords: | Adriamycin-induced nephropathy Rat Animal model E-cadherin Fibronectin |
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