Topoisomerase Mutations in Fluoroquinolone-Resistant and Methicillin-Susceptible and -Resistant Clinical Isolates of Staphylococcus aureus |
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| Authors: | Glenn W. Kaatz and Susan M. Seo |
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| Affiliation: | Department of Internal Medicine, Division of Infectious Diseases, Department of Veteran’s Affairs Medical Center and Wayne State University School of Medicine, Detroit, Michigan 48201 |
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| Abstract: | ![]()
The incidence of the various mutations in the genes encoding topoisomerase IV and DNA gyrase in fluoroquinolone-resistant clinical isolates of Staphylococcus aureus is not known. Using restriction fragment length polymorphism analysis and DNA sequencing, we found that in fluoroquinolone- and methicillin-resistant strains, mutations in grlA and gyrA are quite likely to be present together. For fluoroquinolone-resistant but methicillin-susceptible strains, mutations in grlA alone are more common. |
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