| 大肠癌ICAM-1的表达及临床意义 |
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| 引用本文： | 杨明智,陈积圣,伍衡,王培戈,张敬智,李玉军. 大肠癌ICAM-1的表达及临床意义[J]. 癌症, 2001, 20(3): 311-313 |
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| 作者姓名： | 杨明智 陈积圣 伍衡 王培戈 张敬智 李玉军 |
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| 作者单位： | 中山医科大学孙逸仙纪念医院外科,;青岛医学院附属医院外科,;青岛医学院附属医院病理科, |
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| 摘 要： | 目的：检测大肠癌 ICAM-1的表达探讨其与临床病理因素的关系。方法：应用免疫组织化学方法（ SABC法）,采用 ICAM-1单克隆抗体测定 55例病理证实的大肠癌标本及 8例大肠腺瘤标本中 ICAM-1的表达。结果：大肠癌 ICAM-1阳性 41例,表达率 75％高于大肠腺瘤,差异显著（ P< 0.05） ;发生淋巴结转移的大肠癌 ICAM-1表达率高于未发生转移的大肠癌,差异显著（ P< 0.05）,比较未发生转移的大肠癌与大肠腺瘤 ICAM-1的表达则无显著性差异。结论：大肠癌 ICAM-1的过度表达与淋巴结转移密切相关。
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| 关 键 词： | 细胞间粘附分子-1 大肠肿瘤 免疫组织化学 |
| 文章编号： | 1000-467X（2001）03-0311-03 |
| 修稿时间： | 2000-10-19 |
Expression of ICAM-1 in Colorectal Carcinoma and Its Clinical Significance |
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| YANG Ming-zhi,CHEN Ji-Sheng,WU Heng,WANG Pei-ge,ZHANG Jing-Zhi,LI Yu-Jun. Expression of ICAM-1 in Colorectal Carcinoma and Its Clinical Significance[J]. Chinese journal of cancer, 2001, 20(3): 311-313 |
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| Authors: | YANG Ming-zhi CHEN Ji-Sheng WU Heng WANG Pei-ge ZHANG Jing-Zhi LI Yu-Jun |
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| Abstract: | Objective：This study was designed to determine the expression of ICAM-1 in colorectal cancer and its clinical significance. Methods：The expression of ICAM-1 in 55 samples of colorectal carcinoma and 8 samples of adenomas were invested using immunohistochemical staining. Results：There were 41 positive cases in 55 colorectal cancer samples. The positive rate of ICAM-1 in colorectal cancer was significantly higher than that of adenomas （ P<0.05） , ICAM-1 in colorectal cancer was significantly correlated with lymph node metastasis. However, there was no significantly difference in ICAM-1 expression between adenomas and colorectal cancer without lymph node metastasis. Conclusion： Over-expression of ICAM-1 was significantly related to lymph node metastasis. |
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| Keywords: | ICAM-1 Colorectal carcinoma Immunohistochemistry |
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