Immunochemical Characterization of a Human Antibody to Factor XIII

Dispersed and intact marrow fragmentshave been implanted in the omentum andsubcutaneous fat of irradiated and nonirradiated hosts. Osteogenesis and hemopoiesis in varying proportions wereobserved at 10 and 35 days. The subcutaneous site favored osteogenesis, theomental site and host irradiation prior totransplant resulted in predominance ofhemopoiesis. In dispersed and recompacted marrow grafts, only hemopoiesisdeveloped. Differentiation was predominantly granulocytic. Osteogenesis is notan obligatory prerequisite of hemopoiesisin extramedullary sites.

Submitted on January 31, 1973 Revised on April 23, 1973 Accepted on April 25, 1973