早期移植肾功能异常的相关因素及其预后

目的 探讨早期移植肾功能异常的相关因素及其对移植肾长期存活的影响。方法 根据术后６个月内有无发生急性排斥反应和６个月时的血肌酐水平（ＳＣｒ６月），将２５１例肾移植患者分为４组：Ａ、Ｂ组未发生急性排斥反应，前者ＳＣｒ６月〈１３０μｍｏｌ／Ｌ，后者ＳＣｒ６月≥１３０μｍｏｌ／Ｌ；Ｃ、Ｄ组为４组：Ａ、Ｂ且未发生急性排斥反应，前者ＳＣｒ６月〈１３０μｍｏｌ／Ｌ，后者ＳＣｒ≥１３０μｍｏｌ／Ｌ。术后各组的免

Correlation factors for early graft dysfunction and prognosis after cadaver renal transplantation

Objective To investigate the correlation factors for early graft dysfunction after kidney transplantation, and the effects on longterm graft survival. Methods 251 recipients of first cadaver renal graft were divided into 4 groups according to the history of acute rejection (AR) and the concentration of serum creatinine (SCr) in 6 months after transplantation: Groups A and B, having no history of AR with SCr levels at 6th month of <130mol/L in the former and 130mol/L in the latter, and groups C and D having the history of AR with SCr levels at 6th month of <130mol/L in the former and 130mol/L in the latter. All groups had the same immunosuppressive protocol. Results SCr level at 10th day after operation in groups A and C maintained normal, while the SCr levels in groups B and D were obviously elevated, which was correlated with acute tubular necrosis (ATN), IgA nephritis, donors' age, postoperative hypotension, AR times and the dosage of cyclosporine A. The oneand threeyear survival rate of renal graft in groups D was significantly lower than in groups A, B and C. Conclusion ATN was the commonest cause for early renal graft dysfunction after renal transplantation. The damage to the kidney in the process of renal removal, reperfusion and high dose of cyclosporine A at early stage might affect the recovery of the early renal function. The dysfunction of early renal dysfunction after operation would affect the renal graft longterm survival in the patients having AR in 6 months after operation.