Physical performance in long-term survivors of acute leukaemia in childhood |
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Authors: | P Black P Gutjahr H Stopfkuchen |
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Institution: | (1) Department of Paediatrics, University Hospital, Langenbeckstrasse 1, D-55101 Mainz, Germany, DE |
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Abstract: | The aim of this study was to assess the physical performance in long-term survivors of acute leukaemia in childhood and to
evaluate the effects of anthracycline therapy. Electrocardiography, echocardiography and spiroergometry were carried out on
56 patients aged 9–28 years, of whom 44 patients had been treated with 15–483 mg/m2 doxorubicin (or equivalent). Acute leukaemia had been diagnosed 1.5–16 years earlier. Of the patients 75% reached normal
maximal oxygen uptake, 69% normal oxygen uptake at the anaerobic threshold and 95% normal maximal work rate. Of the patients
75% achieved adequate values for maximal heart rate and 78% normal blood lactate concentration. No difference was seen between
patients treated with and without anthracyclines.
Conclusion The results of this study provide little evidence for cardiopulmonary impairment in long-term survivors of ALL. Both the
cardiac function, as evaluated by ECG and echocardiography, and the physical performance in spiroergometry are normal in a
large number of these patients. Anthracycline treatment does not appear to have a negative effect on these parameters.
Received: 30 October 1996 / Accepted in revised form: 7 October 1997 |
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Keywords: | Childhood cancer Leukaemia Late effects Anthracyclines Exercise testing |
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