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神经氨酸酶抑制剂对流感的临床疗效回顾
引用本文:张石革,马国辉. 神经氨酸酶抑制剂对流感的临床疗效回顾[J]. 中国药业, 2003, 12(11): 33-35
作者姓名:张石革  马国辉
作者单位:北京大学第四临床医学院,北京积水潭医院,北京,100035
摘    要:
目的:病毒神经氨酸酶抑制剂是继金刚烷胺和流感疫苗后的一类全新作用机制的流感防治药物,本介绍其进展和临床对抗流感的效果。方法:采用国内外献综述方法。结果和结论:神经氨酸酶抑制剂能选择性地抑制病毒表面神经氨酸酶的活性,阻止子代病毒颗粒在宿主细胞的复制和释放,有效地预防感冒和缓解症状,在感冒初期应用,可明显缩短疾病的持续时间。

关 键 词:神经氨酸酶抑制剂 流感 流感病毒 临床评估
文章编号:1006-4931(2003)11-0033-02
修稿时间:2003-09-04

Retrospective Study of Clinical Efficacy of the Nueraminidase Inhibitor for the Treatment on the Influenza A and B Virus Infection
Zhang Shige,Ma Guohui. Retrospective Study of Clinical Efficacy of the Nueraminidase Inhibitor for the Treatment on the Influenza A and B Virus Infection[J]. China Pharmaceuticals, 2003, 12(11): 33-35
Authors:Zhang Shige  Ma Guohui
Abstract:
Objective: Nueraminidase inhibitor of infuenza are a novel class of flu therapeutic drugs which have new mechanisms of action different from amantadine and flu vaccine, to summarize the aspect of clinical evaluation for the treatment of influenza A and B virus infection on nueraminidase Inhibitor. Methods:To collecte medical literatures in recent years at home and abroad. Results and Conclusion: Nueraminidase inhibitor can inhibited activity of nueraminidase, provent virus peliet reproduce and released from bing body infection cells. Prevention and lysis symptom of influenza,especialy obvious that of curtail ones time of course of disease.
Keywords:Nueraminidase Inhibitor  Influenza A and B Virus Infection  Influenza Virus  Clinical evaluation
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