| 盐酸黄连素生物黏附包衣片的制备及性质研究 |
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| 引用本文： | 郑玲利,张志荣,訾铁营,袁明勇,黄园. 盐酸黄连素生物黏附包衣片的制备及性质研究[J]. 中国药房, 2010, 0(3): 221-223 |
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| 作者姓名： | 郑玲利 张志荣 訾铁营 袁明勇 黄园 |
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| 作者单位： | 成都医学院第一附属医院药剂科;四川大学华西药学院; |
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| 基金项目： | 成都医学院科研项目计划(CYZ07-010) |
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| 摘 要： | 目的:制备盐酸黄连素生物黏附包衣片并研究其性质。方法:采用正交设计法,确定生物黏附材料羟丙基甲基纤维素、卡波姆934P的用量及配比与制剂体外释放度及黏附力的关系,并对释放度进行释药动力学模拟,根据各模型拟合的残差平方和(Re)、赤池信息准则计算值(AIC)和拟合度(r)值来研究其释药规律。根据Peppas方程特征参数判断其释药机制。结果:羟丙基甲基纤维素与卡波姆对阻滞药物的释放及黏附力影响较大,且卡波姆的效果强于羟丙基甲基纤维素。生物黏附包衣片以Hixson-Crowell方程拟合最佳,药物释放机制为非Fick扩散。结论:盐酸黄连素生物黏附包衣片具有良好的黏附性能和pH依赖性。
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| 关 键 词： | 盐酸黄连素 卡波姆934P 羟丙甲基纤维素K4M 生物黏附 |
Preparation and Property of Berberine Hydrochloride Bioadhesive-coated Tablets |
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| ZHENG Ling-li,ZI Tie-ying,YUAN Ming-yong ZHANG Zhi-rong,HUANG Yuan. Preparation and Property of Berberine Hydrochloride Bioadhesive-coated Tablets[J]. China Pharmacy, 2010, 0(3): 221-223 |
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| Authors: | ZHENG Ling-li ZI Tie-ying YUAN Ming-yong ZHANG Zhi-rong HUANG Yuan |
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| Affiliation: | ZHENG Ling-li,ZI Tie-ying,YUAN Ming-yong(Dept.of Pharmacy,The First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China) ZHANG Zhi-rong,HUANG Yuan(West China Pharmacy School of Sichuan University,Chengdu 610041,China) |
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| Abstract: | OBJECTIVE: To prepare Berberine hydrochloride bioadhesive-coated tablet and study its property. METHODS: Orthogonal design was used to determine the relation of the amount as well as proportion of hypromellose and Carbomer 943P with in vitro release and adhesive force of the tablets. The value of fitting Re,AIC and r were used as comprehensive indexes to select the best imitating model. And the release mechanism was determined according to the parameters of Peppas equation. RESULTS: Hypromellose and Carbome... |
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| Keywords: | Berberine hydrochloride Carbopol 934P Hypromellose Bioadhesive |
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