| 色谱手性固定相在手性药物拆分中的应用 |
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| 引用本文： | 杜会霞,尹大力. 色谱手性固定相在手性药物拆分中的应用[J]. 中国新药杂志, 2006, 15(24): 2099-2102 |
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| 作者姓名： | 杜会霞 尹大力 |
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| 作者单位： | 中国医学科学院,中国协和医科大学药物研究所,北京,100050 |
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| 摘 要： | 色谱手性固定相（chiral stationary phases，CSPs）在手性药物分析和制备拆分中具有很重要的作用。本研究对5种带有CSPs的手性色谱技术以及在高效液相色谱（high performance liquid chromatography，HPLC）和超临界流体色谱（supereritical fluid chromatography，SFC）中CSPs的4种流动相模式和6种类型进行了综述，提出了CSPs色谱柱的筛选策略，并讨论了手性药物拆分从分析到制备的转变。
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| 关 键 词： | 手性固定相 对映体 色谱 拆分 |
| 文章编号： | 1003-3734（2006）24-2099-04 |
| 收稿时间： | 2006-05-10 |
| 修稿时间： | 2006-05-10 |
Application of chiral stationary phases of chromatography on resolution of chiral drugs |
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| DU Hui-xia,YIN Da-li. Application of chiral stationary phases of chromatography on resolution of chiral drugs[J]. Chinese Journal of New Drugs, 2006, 15(24): 2099-2102 |
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| Authors: | DU Hui-xia YIN Da-li |
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| Affiliation: | Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China |
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| Abstract: | Chiral stationary phases (CSPs) have the potential for the analytical and preparative resolution of chiral drugs by chromatographies.This paper highlights five categories of chromatographic techniques with CSPs,four mobile-phase regimens in HPLC-Supercritical Fluid Chromatography (SFC) CSPs and six categories of HPLC-SFC CSPs.The strategies for the selection of chromatographic columns with CSPs and the transit of preparative processes from analytical processes by CSPs in the resolution of chiral drugs are also addressed. |
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| Keywords: | chiral stationary phases enantiomers chromatography resolution |
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