分化型甲状腺癌中血清TSH与VEGF表达的相关性

目的 观察分化型甲状腺癌(differentiated thyroid carcinoma，DTC)中血清促甲状腺激素(thyroid stimulating hormone ，TSH)浓度与肿瘤组织中血管内皮生长因子(vascular endothelial growth factor ， VEGF)表达的相关性。方法 统计及分析43名DTC患者术前测定的TSH血清浓度及肿瘤组织中的VEGF免疫组织化学表达情况，使用统计方法了解两者的相关性。结果 VEGF主要在DTC肿瘤细胞的胞质内和胞膜上表达,其阳性率为90.7%，同时随TSH浓度的升高VEGF的表达也相应升高，两者呈正相关（r=0.592， P＜0.01）。结论 TSH水平与VEGF表达呈正相关，与DTC的发生发展及预后有关。

Relationship between Preoperative Serum TSH Levels and Expression of VEGF in Differentiated Thyroid Carcinoma

ObjectiveTo elucidate whether immunohistochemical expression of VEGF is related to serum TSH level.MethodsThe VEGF expression was analyzed in 43 archived differentiated thyroid carcinoma specimens using immunohistochemistry.The adjacent normal thyroid tissues were used as controls.TSH in serum samples from 43 patients was measured by immunoradiometric assay before surgery.A statistical correlationwas observed between serum TSH levels and VEGF expression in DTC tissues.ResultsThe incidences of positive expression were 90.7% for VEGF in 43 DTC tissues,while 0% in normal tissues.The serum TSH levels revealed a significant positive correlation with VEGF expression （r=0.592，P＜0.01）.ConclusionThe serum TSH levels reveal a significant positive correlation with VEGF expression,and they maypredict the initiation,progression and prognosis of differentiated thyroid carcinoma.