EXPRESSION OF P53 GENE IN ORAL SQUAMOUS CELL CARCINOMA AND ITS RELATION WITH CLINICAL AND PATHOLOGICAL PARAMETERS AND PROGNOSIS OF PATIENTS

One hundred and eleven cases of cral squamous cell carcinoma (OSCC) were examined for overexpression of p53 protein by using immunchistochemical technique.Association between p53 protein overexpression and clinical and pathological parameters as well as prognosis of patients were also analyzed. p53 protein overexpression was commonly observed (69.4%) in OSCC and may be used as a marker of carcinogenesis of OSCC.The level of p53 protein overexpression is correlated with the lowet three and five-year survival rate of OSCC.The presence of absence of p53 overexpression was not correlated with sex,age,site of tumor,size of tumor,degree of differentiation,node status,and clinical stage in OSCC.Single factor COX proportinoal hazards regression model analysis indicated that there was no significant association between p53 overexpression and prognosis of OSCC,Multivariable COX model analysis failed to establish effective life function of risk rate function,These showed that all the parameters analyzed in this study as well as p53 overexpression were not significant and effective risk factors of prognosis for patients wich OSCC.