致细菌性阴道病的凝固酶阴性葡萄球菌体外抗菌活性分析

目的：研究凝固酶阴性葡萄球菌（CNS）的 耐药性及其与细菌性阴道病的关系。方法：采用高效甘露醇平板进行细菌的分离，肉汤稀释法检测得最小抑菌浓度（MIC）。结果：分离出18株CNS，分离率为42％，对氨苄西林低水平耐药，对克林霉素和洛美沙星中度耐药，对红霉素和大观霉素高度耐药。结论：CNS耐药性的改变，为其致细菌性阴道病的原因之一。

In vitro antibiotic resistance analysis of coagulase-negative staphylococci isolated from bacterial vaginosis

ABSTRACT:Objective: To study the antibiotic resistance of coagulase-negative staphylococci and its relationshipwith bacterial vaginosis. Methods: Bacteria were isoalated by high salt mannitol medium and resistance to antibiotic wasdetected by serial dilution broth method. Result: 18 strains of coagulse-negative staphylococci were cultured in the 43samples, the cultue rate was 42%; and they were slight resistant to ampicillin, moderate resistant to clindamycin andlomefloxacin, and severe resistance to spectinomycin and erythromycin. Conclusion: The alternation of antibioticresistance of coagulase negative staphylococci may be due to baterial vaginosis.