Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population: Findings from the China Cardiometabolic Disease and Cancer Cohort (4C) Study |
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| Authors: | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang |
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| Affiliation: | 1. Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;2. Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;3. The First Hospital of Jilin University, Changchun 130021, Jinlin, China;4. Qilu Hospital of Shandong University, Jinan 250012, Shandong, China;5. Affiliated Hospital of Guiyang Medical College, Guiyang 550004, Guizhou, China;6. Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, China;7. Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, Hubei, China;8. Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong, China;9. The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China;10. The Affiliated Hospital of Southwest Medical University, Luzhou 646099, Sichuan, China;11. Fujian Provincial Hospital, Fujian Medical University, Fuzhou 350001, Fujian, China;12. Dalian Municipal Central Hospital, Dalian 116003, Liaoning, China;13. The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China;14. The First Affiliated Hospital of Guangxi Medical University, Nanning 530021, Guangxi, China;15. Jiangxi Provincial People''s Hospital Affiliated to Nanchang University, Nanchang 330006, Jiangxi, China;p. The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, Heilongjiang, China;q. Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, Zhejiang, China;r. Central Hospital of Shanghai Jiading District, Shanghai 201800, China;s. Jiangsu Province Hospital on Integration of Chinese and Western Medicine, Nanjing 210028, Jiangsu, China;t. The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui, China;u. Karamay Municipal People''s Hospital, Karamay 830054, Xinjiang, China;v. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China;w. The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China;x. Shandong Provincial Hospital affiliated to Shandong University, Jinan 250021, Shandong, China;y. Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei, China;z. Chinese People''s Liberation Army General Hospital, Beijing 100853, China;11. The First Hospital of Lanzhou University, Lanzhou 730000, Gansu, China |
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| Abstract: | ![]()
Objective The relationship between serum uric acid (SUA) levels and glycemic indices, including plasma glucose (FPG), 2-hour postload glucose (2h-PG), and glycated hemoglobin (HbA1c), remains inconclusive. We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population. Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study. A total of 105,922 community-dwelling adults aged ≥ 40 years underwent the oral glucose tolerance test and uric acid assessment. The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models. Results A total of 30,941 men and 62,361 women were eligible for the current analysis. Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels, but with different inflection points in men and women. The thresholds for FPG, 2h-PG, and HbA1c for men and women were 6.5/8.0 mmol/L, 11.0/14.0 mmol/L, and 6.1/6.5, respectively (SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices). Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes, while the inflection points were reached earlier in men than in women. |
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| Keywords: | Cross-sectional study Serum uric acid Glycemic index Glycemic status |
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