灯盏细辛联合低分子肝素治疗肾病综合征的临床疗效观察

目的 探讨灯盏细辛联合低分子肝素治疗肾病综合征的临床疗效.方法 回顾性分析2009年1月至2010年12月在河池市中医院治疗的78例原发性肾病综合征患者的临床资料,随机分为2组,对照组39例与治疗组39例.对照组采用常规治疗,治疗组在常规治疗基础上加用灯盏细辛联合低分子肝素治疗,疗程约2周.观察治疗后患者24 h尿蛋白、血清甘油三酯(TG)、总胆固醇(Chol)、血清白蛋白(ALB)以及活化部凝血活酶时间(APTT)、纤维蛋白原(FIB).并且观察2组的疗效.结果 与对照组疗效(71.8％)比较,治疗组有效率(92.3％)高.疗效明显改善,差异有统计学意义(P＜0.05).与对照组相比,治疗组24 h尿蛋白明显降低,血清白蛋白明显增多,血清甘油三酯和总胆同醇明显降低.活化部凝血活酶时间明显延长、纤维蛋白原明显降低,差异有统计学意义(P＜0.05).结论 灯盏细辛联合低分子肝素明显增加原发性肾病综合征患者尿量和尿蛋白、降低血脂,改善高凝状态,提高血清白蛋白,对原发性肾病综合征具有良好的治疗效果.

Clinical Effect of Herba Erigerontis Breviscapi Combined with Low Molecular Heparin on Nephrotic Syndrome

Objective To explore the clinical effect of Herba Erigerontis Breviscapi combined with low molecular heparin on nephrotic syndrome.Methods We performed a retrospective analysis on the clinical data of 78 patients with primary nephrotic syndrome patients in our hospital from January 2009 to December 2010.The patients were randomly divided into two groups: treatment group and control group,with 39 cases in each group.Patients in the control group were given conventional treatment.Patients in the treatment group were given Herba Erigerontis Breviscapi combined with low molecular heparin besides conventional treatment.The treatment period lasted for about two weeks.The levels of urine protein,serum triglyceride(TG),total cholesterol(Chol),serum albumin(ALB)and activation of blood coagulation enzyme time(APTT),fibrinogen(FIB)of patients in two groups were tested and the clinical effect was compared between two groups.Results The curative effect of the treatment group was better than the control group,with the effective rate of 92.3% and 71.8%(P<0.05).Compared with the control group,the treatment group,there was a signinicant increase of 24 h urine protein,and a significant increase of serum albumin,serum triglyceride and total cholesterol in patients in treatment group.The active site blood coagulation time was significantly longer and the fibrinogen(FIB)was reduced in treatment group than control group.Conclusion Herba Erigerontis Breviscapi combined with low molecular heparin can improve the levels of urinary albumin,decrease the blood lipids levels,improve the high coagulative state and improve the serum albumin levels of primary nephrotic syndrome patients,so has good therapeutic effect.