三氯羟基二苯醚醇消毒凝胶消毒性能的研究

为了解三氯羟基二苯醚含醇消毒凝胶杀菌作用及理化性能,采用载体定量杀菌试验和理化分析方法进行了实验室和现场实验观察。结果,以含质量分数1.55%的三氯羟基二苯醚和39.6%乙醇组成的消毒凝胶、pH值6.67条件下,对布片上的金黄色葡萄球、铜绿假单胞杆菌、大肠杆菌和白色念珠菌作用0.5 m in,杀灭对数值均>5.00。用标准硬水将该消毒凝胶作对倍稀释,对金黄色葡萄球和白色念珠菌,作用1.0 m in,杀灭对数值分别为3.40和2.75。用该消毒凝胶原液对志愿者手及前臂皮肤进行擦拭消毒1.0 m in,对手部皮肤自然菌的杀灭对数值均>1.00。将该消毒凝胶原包装产品置于37℃恒温储存3个月,有效成分三氯羟基二苯醚和乙醇含量下降率分别为1.94%和1.01%。结论,三氯羟基二苯醚醇消毒凝胶对细菌繁殖体和真菌具有快速杀灭作用,对志愿者手皮肤上自然菌杀灭效果达到消毒合格要求,储存性能稳定。

STUDY ON DISINFECTION PROPERTIES OF TRICLOSAN ALCOHOL DISINFECTION GEL

In order to know the germicidal efficacy and physicochemical properties of triclosan disinfection gel containing alcohol,carrier quantitative germicidal test and physicochemical analysis method were used to carry out laboratory and field experimental observation.Results: The killing logarithm values of Staphylococcus aureus,Pseudomonas aeruginosa,Escherichia coli and Candida albicans on cloth strips exposed to the disinfection gel composed of 1.55%(m/m) triclosan and 39.6% ethanol(pH 6.67) for 0.5 min were >5.00.The killing logarithm values of S.aureus and C.albicans exposed to the disinfection gel double diluted with standard hard water for 1.0 min were 3.40 and 2.75 respectively.The killing logarithm value of the natural bacteria on skin of hands of volunteers after wiping disinfection of their forearms and hands with the stock solution of the disinfection gel for 1.0 min was >1.00.After the disinfection gel in original packing was stored at constant termperature of 37℃ for 3 months,the contents of its active principles triclosan and ethanol decreased by 1.94% and 1.01% respectively.Conclusions: Triclosan alcohol disinfection gel has rapid efficacy in killing vegetative forms of bacteria and fungi.Its efficacy in killing natural bacteria on skin of hands of volunteers fulfils the requirement of eligible disinfection.It is stable on storing.