CO2 dissociation curves of oxygenated whole blood obtained at rest and in exercise |
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Authors: | Miharu Miyamura Prof Dr Yoshiyuki Honda |
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Institution: | (1) Research Center of Health, Physical Fitness and Sports, Nagoya University, Nagoya, Japan;(2) Department of Physiology, Chiba University School of Medicine, 280 Chiba, Japan |
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Abstract: | Summary In vitro CO2 dissociation curves for oxygenated whole blood were determined in 19 healthy male subjects at rest and during submaximal
and maximal bicycle work. Hemoglobin concentration and blood lactate increased with increasing work load and accordingly buffer
value of the whole blood increased while bicarbonate and Base Excess (BE) decreased, resulting in a downward shift of the
CO2 dissociation curve during exercise. Despite the marked increase in buffer values of the blood, the slopes of the CO2 dissociation curves during exercise were found to be about the same as those obtained at rest. It was inferred that the increasing
effect of increased buffer value, on the dissociation slope, was essentially compensated by the decreasing effect of diminished
bicarbonate content. The advantages of this relatively constant CO2 dissociation slope for the indirect measurement of cardiac output by the Fick principle are discussed. |
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Keywords: | CO2 dissociation curve Rest and exercise Bicycle work Buffer value Bicarbonate |
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