| 葛根素缓释微球的高分子材料考察及制备工艺优选 |
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| 引用本文： | 周雪,贺智勇,薛雨晨,朱娅芳,朱瑞,沈祥春,陶玲.葛根素缓释微球的高分子材料考察及制备工艺优选[J].中国实验方剂学杂志,2015,21(9):14-18. |
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| 作者姓名： | 周雪 贺智勇 薛雨晨 朱娅芳 朱瑞 沈祥春 陶玲 |
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| 作者单位： | 贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004,贵阳医学院 中药药剂学教研室, 贵阳 550004;贵阳医学院 天然药物优效利用重点实验室, 贵阳 550004 |
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| 基金项目： | 贵州省国际科技合作计划项目(黔科合G字[2012]7041号);贵州省科学技术基金项目(黔科合J字[2013]2039);贵州省科技厅联合基金项目(黔科合LG字[2011]018号);贵阳市科技局大学生创新课题(黔科合同2012[2]) |
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| 摘 要： | 目的:筛选葛根素缓释微球的高分子材料并优选其制备工艺。方法:采用乳化溶剂挥发法制备葛根素缓释微球,以包封率、载药量及收率的综合加权评分为指标,通过正交试验优选高分子材料,考察投药量、聚乳酸(PLA)用量和聚乙烯醇(PVA)质量分数对葛根素缓释微球处方工艺的影响。采用扫描电镜(SEM)、综合热分析(TGA)、差示扫描热分析(DSC)及X射线衍射法(XRD)对微球进行表征。结果:葛根素缓释微球最适高分子材料为PLA,最佳制备工艺为投药量37.5 mg,PLA用量80 mg,PVA质量分数0.5%。葛根素缓释微球表面光滑圆整,无黏连,平均粒径104.3μm,载药量(26.20±2.24)%,包封率(68.92±1.88)%,收率(83.97±2.55)%;TGA,DSC,XRD等证实制备成微球后葛根素与聚合物分子空间结构可能发生了物理形式的变化。结论:采用乳化溶剂挥发法成功制备了葛根素缓释微球,工艺简单合理、操作稳定。
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| 关 键 词： | 葛根素 聚乳酸 微球 乳化溶剂挥发法 综合热分析 |
| 收稿时间： | 2014/7/31 0:00:00 |
Investigation of Polymer Materials and Optimization of Preparation Process of Puerarin Sustained-release Microspheres |
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| ZHOU Xue,HE Zhi-yong,XUE Yu-chen,ZHU Ya-fang,ZHU Rui,SHEN Xiang-chun and TAO Ling.Investigation of Polymer Materials and Optimization of Preparation Process of Puerarin Sustained-release Microspheres[J].China Journal of Experimental Traditional Medical Formulae,2015,21(9):14-18. |
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| Authors: | ZHOU Xue HE Zhi-yong XUE Yu-chen ZHU Ya-fang ZHU Rui SHEN Xiang-chun and TAO Ling |
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| Institution: | Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China,Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China,Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China,Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China,Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China,Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China and Department of Chinese Drugs Pharmaceutics, Guiyang Medical University, Guiyang 550004, China;Key Laboratory of Optimal Utilization of Natural Medicine Resources, Guiyang Medical University, Guiyang 550004, China |
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| Abstract: | |
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| Keywords: | puerarin polylactic acid microspheres emulsion solvent evaporation method thermogravimetric analysis |
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