| 大鼠自体移植静脉内膜增生模型的改进 |
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| 引用本文： | 苏刚,孙宗全,董念国,陈家军. 大鼠自体移植静脉内膜增生模型的改进[J]. 华南国防医学杂志, 2006, 20(6): 10-12 |
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| 作者姓名： | 苏刚 孙宗全 董念国 陈家军 |
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| 作者单位： | 华中科技大学同济医学院附属协和医院心外科,武汉,430022 |
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| 摘 要： | 目的改进大鼠自体移植静脉内膜增生模型,比较采用不同方法建立模型的效果。方法将36只SD大鼠随机分成2组:实验组和对照组。实验组采用“套管法”将大鼠自体颈外静脉移植入同侧颈动脉系统。对照组采用“吻合法”行自体颈外静脉移植,术后均给予肝素皮下注射5天。观察术后不同时间点两组大鼠移植静脉通畅性、吻合口狭窄及内膜增生情况。结果实验组移limit自体移植静脉通畅性优于对照组,吻合口狭窄程度轻于对照组。结论实验组模型设计科学,手术操作简便,成功率高。
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| 关 键 词： | 动物模型 自体移植静脉 内膜增殖 大鼠 |
| 收稿时间： | 2006-06-16 |
| 修稿时间： | 2006-06-16 |
Improved model of Autogenous Vein Graft Intimal Hyperplasia in Rats |
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| SU Gang, SUN Zong-quan , DONG Nianguo ,et al.. Improved model of Autogenous Vein Graft Intimal Hyperplasia in Rats[J]. Military Medical Journal of South China, 2006, 20(6): 10-12 |
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| Authors: | SU Gang SUN Zong-quan DONG Nianguo et al. |
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| Affiliation: | Department of Cardiiovascular Surgery, Union Hospital, Tongji Medical School, Huazhong University of Science and Technology, Wuhan Hubei 430022 ,China |
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| Abstract: | Objective To explore the modified "cuff" technique to establish an animal model of intimal hyperplasia of autologous vein graf in rats.Methods Thirty-six SD rats were divided into experimental and control groups.The external jugular vein were implanted into the external carotid of the same side respectively by the anastomosis and the "Cuff"technique in the experimental and control groups .The animals were given heparin(800 units/ kg, twice a day)for 5 days after the operation.The implannted the autogenous veins were observed respectively 2,4 and 8 weeks after the operation in the two group rats.Result The walls of the implanted autogenous veins were smoother in the experimental group than those in the control group .Conclusion The artery bypass graft estalished by "cuff"technique is better than that by anastomosis technique. |
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| Keywords: | Autogenous vein graft Intimal hyperplasia Animal model Rats |
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