银杏酮酯滴丸对脑动脉硬化眩晕伴高同型半胱氨酸血症患者疗效观察

【目的】观察银杏叶提取物银杏酮酯滴丸对脑动脉硬化眩晕伴高同型半胱氨酸血症患者疗效的影响。【方法】将66例患者随机分为对照组和治疗组,每组各33例。2组患者均给予西医常规治疗,在此基础上,治疗组给予银杏酮酯滴丸治疗,对照组给予银杏酮酯滴丸安慰剂治疗,2周为1个疗程,共治疗2个疗程。观察2组患者治疗前后头晕目眩、头痛、舌质紫暗等各项中医证候积分和血中同型半胱氨酸(Hcy)水平的变化情况,评价2组患者的眩晕控制疗效。【结果】(1)治疗4周后,治疗组和对照组的总有效率分别为93.9%(31/33)和69.7%(23/33),治疗组的眩晕控制疗效明显优于对照组(P<0.05)。(2)治疗2周后,治疗组的各项中医证候积分均较治疗前明显降低(P<0.05),而对照组的各项中医证候积分与治疗前比较均无明显降低(P>0.05);治疗4周后,2组患者的各项中医证候积分均较治疗前明显降低(P<0.05);组间比较,治疗组在治疗2周和4周后对各项中医证候积分的降低作用均明显优于对照组(P<0.05)。(3)治疗2周和4周后,2组患者的Hcy水平均较治疗前明显降低(P<0.01),且治疗组治疗2周和4周后对Hcy水平的降低作用均明显优于对照组(P<0.05或P<0.01)。【结论】银杏酮酯滴丸治疗脑动脉硬化眩晕伴高同型半胱氨酸血症患者疗效确切,可有效降低Hcy水平,这可能是其有效控制脑动脉硬化眩晕的机制之一。

Clinical Effect of Ginkgo Flavonoids Ester Drop Pills for Treatment of Cerebral Arteriosclerosis Induced Vertigo Accompanying with Hyperhomocysteinemia

Objective To investigate the clinical effect of Ginkgo Flavonoids Ester Drop Pills for the treatment of cerebral arteriosclerosis induced vertigo accompanying with hyperhomocysteinemia.Methods Sixty-six qualified patients were randomly divided into control group and treatment group,with 33 cases in each group.The two groups were given conventional western medicine treatment,and additionally,the treatment group was given Ginkgo Flavonoids Ester Drop Pills orally and the control group was given placebo drop pillsorally.Two weeks constituted a course of treatment,and the treatment lasted for 2 courses.Before and after treatment,the scorese of traditional Chinese medicine(TCM)syndrome such as vertigo,headache,and dark pruplish tongue as well as blood homocysteine(Hcy)level in the two groups were observed.After treatment,the efficacy for controlling vertigo in the two groups was evaluated.Results(1)After 4 weeks of treatment,the total effective rate for controlling vertigo in the treatment group was 93.9%(31/33)and that in the control group was 69.7%(23/33).The intergroup comparison showed that the clinical efficacy for controlling vertigo in the treatment group was superior to that in the control group,and the difference was statistically significant(P<0.05).(2)After treatment for 2 weeks,the scores of various TCM symptoms in the treatment group were much lower than those before treatment(P<0.05),but the scores of various TCM symptoms in the control group showed no obvious changes(P>0.05).After treatment for 4 weeks,the scores of various TCM symptoms in the two groups were much lower than those before treatment(P<0.05).The intergroup comparison showed that the decrease of the scores of various TCM symptoms in the treatment group was superior to that in the control group after treatment for 2 and 4 weeks(P<0.05).(3)After treatment for 2 and 4 weeks,Hcy level in the two groups were significantly decreased in comparison with that before treatment(P<0.01),and the decrease of Hcy level in treatment group was superior to that in the control group after treatment for 2 and 4 weeks(P<0.05 or P<0.01).Conclusion Ginkgo Flavonoids Ester Drop Pills exert certain effect for the treatment of cerebral arteriosclerosis induced vertigo accompanying with hyperhomocysteinemia.The pills are effective on decreasing the Hcy level,which may be one of the mechanisms for the treatment of cerebral arteriosclerosis induced vertigo.